The 8 Most Important Things You Need to Know About NMN

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The 8 Most Important Things You Need to Know About NMN

You cannot enjoy robust health if your body doesn't manufacture energy. Unfortunately, as we age, we gradually become increasingly less energetic simply because our bodies produce less of it.

NMN may be a way to cheat Father Time.

Led by Shin-ichiro Imai, MD, PhD, a professor of developmental biology and of medicine, researchers at Washington University School of Medicine in St. Louis have shown that supplementing healthy mice with a natural compound called NMN can compensate for this loss of energy production, reducing typical signs of aging such as gradual weight gain, loss of insulin sensitivity and declines in physical activity [1] .

In skeletal muscle, the investigators discovered that NMN administration helps energy metabolism by improving the function of mitochondria, which operate as cellular power plants.

They also found that mice given NMN:

  • Gained less weight with aging even as they consumed more food, likely because their boosted metabolism generated more energy for physical activity;
  • Gained better function of their retina, as well as increased tear production (often lost with aging);
  • Developed improved insulin sensitivity, and this improvement remained significant even when they corrected for differences in body weight.

The best form of NMN currently available is the sublingual form, as it gets absorbed into your bloodstream. Our ProHealth NMN Pro combines pure NMN (that’s verified by a lab report and included in every product package shipped to our customers) and xylitol, a remarkable, natural non-sugar sweetener that enhances bioavailability.

Read on to learn about the very important health benefits offered by NMN and why the sublingual form is best.

#1. Sublingual NMN is the Best NAD+ Booster

The remarkable things that NMN can do to improve your health and help you age better is due to its ability to boost NAD+, and that best happens when the NMN can actually enter your bloodstream.

As you’ll see in the next section, NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in all living cells, and is necessary for the fundamental biological processes that make life possible.

NAD+ has two general sets of reactions in the human body: helping turn nutrients into energy as a key player in metabolism and working as a helper molecule for proteins that regulate other biological activity. These processes are incredibly important because they are responsible for regulating oxidative stress and circadian rhythms while maintaining the health of DNA and keeping humans healthier for longer.

Unfortunately, NAD+ levels decline as we age, and we simply can’t consume this molecule directly to make up for its decline in our body. That’s why we need to take an NMN sublingual precursor to NAD+ that will boost its levels.

NMN Needs To Enter Your Bloodstream

Taken in a capsule, NMN is primarily digested in the gastrointestinal tract and processed in the liver. However, in sublingual form - where it’s dissolved under your tongue - NMN can bypass the stomach and liver and circulate in your blood where it’s needed [2] .

The absorption of molecules delivered through the sublingual route can be 3 to 10 times greater than oral route delivered via capsule, and is only surpassed by direct IV injection [3] .

Prohealth Longevity pays attention to what scientific research reveals, and that’s why our NMN is made in the sublingual form.

#2. NMN Can Reverse Aging of Blood Vessels and Grow Muscle

Vascular aging causes many diseases - cardiovascular, neurological, muscle wasting, frailty, and even aging. As we age, the smallest blood vessels in our bodies wither and die, reducing the blood flow to organs and tissues.

Harvard professor, Dr. David Sinclair’s experiments with mice have demonstrated a way to reverse blood vessel aging and grow muscle.

Dr. Sinclair is among the most renowned anti-aging scientists in the world, and is an expert on NAD+ and NMN. He reports that the NAD+ boosting NMN compound reverses aging in blood vessels and restores muscle strength, while increasing exercise endurance [5] .

A 2018 research study used NMN as the precursor to increase NAD+ levels. Commenting on the study, Dr. Sinclair said:

“We’ve discovered a way to reverse vascular aging by boosting the presence of naturally occurring molecules in the body that augment the physiological response to exercise” adding, "The approach stimulates blood vessel growth and boosts stamina and endurance in mice and sets the stage for therapies in humans to address the spectrum of diseases that arise from vascular aging." [6]

Old blood vessels become deaf to the signals from exercise muscles, which results in muscles shrinking as we age and a diminished capacity to exercise and grow new blood vessels.

This muscle tissue loss and weakness that happens as we grow older is a condition called sarcopenia. Physically inactive people can lose as much as 3% to 5% of their muscle mass each decade after age 30.

At some point from 75 onward, some amount of muscle attrition occurs even with exercise. Any loss of muscle matters because it lessens strength and mobility, often leading to instability and a higher chance of falling [7] .

Cognizant of the effects of sarcopenia, Dr. Sinclair and his research associates decided to examine why exercise loses its protective power to sustain muscle vitality and whether this process is reversible.

The signaling cross-talk between blood vessels and muscles requires NAD+ and sirtuin1, or SIRT1. NAD+ boosts SIRT1, which in turn enables the signaling conversation between muscles and blood vessels. The problem is that both NAD+ and SIRT1 decline as we age and eventually can no longer perform their role as the interface between muscles and blood vessels.

In Dr. Sinclair’s study, mice were given NMN which boosted NAD+ levels and in turn boosted SIRT1. The results were that these mice had better endothelial function, blood vessel growth and improved blood supply to their muscles.

#3. NMN Can Lower Your Body Fat

Weight gain and weight loss resistance are common struggles for countless people across the world. NMN is a powerful nutraceutical ally in weight loss efforts because it reverses insulin resistance, improves glucose tolerance, and ameliorates mitochondrial dysfunction, three factors that contribute to stubborn weight issues.

Shin-ichiro Imai, MD, PhD from the Washington University School of Medicine conducted an experiment on mice to see if NMN could augment their NAD+ levels by converting NMN to NAD. The results were so startling that Time magazine wrote a feature article about the experiment [8] .

Remarkably, this study showed that old mice could be made young, thin, and energetic again with NMN. The researchers showed, at least in mice, aging could be reversed with NMN supplementation [9] .

In Dr. Imail’s study, mice fed low-dose NMN lost 4% of their body weight. Those fed high-dose NMN lost 9% of their body weight.

#4. NMN Can Increase Your Energy

The mitochondria are the energy power plants of cells. In Dr. Imai’s study, mice given NMN were much more energetic and had better energy production from their mitochondria.

Indeed, the most important NAD+ precursor for mitochondrial synthesis is NMN [10] .

During the course of Dr. Imai’s experiment, NMN-consuming mice switched their primary energy source from glucose to fatty acids. The overall results from the experiment “strongly suggest that NMN has significant preventive effects against age-associated impairment in energy metabolism..." [11] .

#5. NMN Can Improve Your Insulin Sensitivity

Mice on NMN showed much better insulin sensitivity. Better insulin sensitivity means less diabetes. Even heavier mice on NMN showed better insulin sensitivity.

Consistent with these insulin results, after 12 months of NMN administration, NMN-fed mice showed significantly improved insulin sensitivity compared to the body weight-matched control group [12] .

#6. NMN Can Improve Your Heart

The human heart requires a continuous supply of ATP to fuel its muscular contractions and sustain life. ATP is short for Adenosine Triphosphate, a molecule known in biochemistry as the "molecular currency" of intracellular energy transfer; meaning that ATP stores and transports chemical energy within cells.

Without ATP we would soon die, but that doesn’t happen. What does happen is Interruptions in the heart’s ATP supply, which can impair cardiac and vascular function and contribute to the development of cardiovascular disease.

By enhancing the biosynthesis of NAD+, an essential substrate in ATP-producing reactions, NMN boosts cardiac ATP levels and significantly improves heart health. Importantly, NMN also reduces arterial aging and vascular dysfunction, two phenomena that play crucial roles in the pathogenesis of cardiovascular disease [13] .

#7. Alzheimer's Symptoms Improved with NMN

Alzheimer’s is a chronic neurodegenerative disease that usually starts slowly and worsens over time. It is the cause of 60 to 70% of cases of dementia. The most common early symptom is difficulty in remembering recent events or newly learned information (short-term memory loss).

Although nearly 60% of the world’s population thinks that Alzheimer’s is a typical part of aging, it is not. It can be avoided [14] .

For most people, scientist think that Alzheimer's disease is caused by a combination of genetic, lifestyle and environmental factors that affect the brain over time, with genetics being the most minor cause; just 1% [15] .

The exact causes of Alzheimer's disease aren't fully understood, but at its core are problems with brain proteins that fail to function normally, disrupt the work of brain cells (neurons) and unleash a series of toxic events. Neurons are damaged, lose connections to each other and eventually die.

The damage most often starts in the region of the brain that controls memory, but the process begins years before the first symptoms. The loss of neurons spreads in a somewhat predictable pattern to other regions of the brains. By the late stage of the disease, the brain has shrunk significantly.

The good news is that NMN may help decrease the causes of Alzheimer’s. A study published in 2107 concluded that:

“NMN decreased β-amyloid production, amyloid plaque burden, synaptic loss, and inflammatory responses in AD-Tg mice.” [Mice that mimic a range of Alzheimer's disease-related pathologies.] [16]

#8. NMN Can Help Repair DNA

Your DNA is the blueprint for your body’s physiological function. When proper DNA expression is altered because of an unhealthy diet, environmental toxins and aging, then your body’s DNA blueprint can be altered. Should this happen, chronic health conditions can develop, such as cancer, diabetes, and neurological dysfunction. NMN helps prevent adverse changes in gene expression by repairing damaged DNA [17] .

Show references
  1. Science Daily: Natural compound reduces signs of aging in healthy mice.
  2. Ling Liu: Quantitative Analysis of Redox Metabolism.
  3. Neha Narang, Jyoti Sharma: Sublingual Mucosa As A Route For Systemic Drug Delivery.
  4. Healthline: Xylitol, Everything You Need to Know.
  5. David Sinclair, et al: Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging
  6. EKATERINA PESHEVA: Rewinding the Clock
  7. WebMD: Sarcopenia With Aging.
  8. Alice Park: How This Broccoli Enzyme Can Slow Aging.
  9. Shin-ichiro Imai, et al: Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice.
  10.  Antonio Lucena-Cacace, et a: Nicotinamide phosphoribosyltransferase: Biology, role in cancer, and novel drug target.
  11.  Shin-ichiro Imai, et al: Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice.
  12.  Ibid
  13.  Yamamoto T, et al: Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion.
  14.  Alzheimer's Association:
  15.  Mayo Clinic: Alzheimer’s Disease.
  16.  Yao Z, et al: Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease.
  17.  Jun Li, et al: A conserved NAD+ binding pocket that regulates protein-protein interactions during aging.
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