The Energy-boosting NAD Supplement You Need For Vital Health

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The Energy-boosting NAD Supplement You Need For Vital Health

The research results keep pouring in that attest to the anti-aging benefits of a NAD supplement that helps your cells produce more energy, and delay the detrimental effects of aging. The latest is a study published on June 13th in the journal Cell Metabolism, which has identified a novel approach to boosting a certain protein enzyme that helps cells make energy.

I'm going to tell you about this research in a moment, but first I'll tell you right up front that the NAD supplement that conferred certain anti-aging benefits is NNM, short for Nicotinamide Mononucleotide, a derivative of niacin.  

NAD is also an acronym, which stands for Nicotinamide adenine dinucleotide, a molecule found in every cell in the body. NAD is used to power metabolism by enabling the mitochondria - the 'power stations' of the cell -  to convert the food we eat into the energy our body needs to sustain all its functions. As reported on ProHealth Longevity, restoring NAD levels to youthful levels with NMN supplementation can reverse many of the symptoms of chronic disease and aging and maintain cellular energy at youthful levels.

Let's now turn to the study summarized in Cell Metabolism. The research was done by scientists from Washington University School of Medicine in St. Louis. 

The NAD Supplement NMN Boosts eNAMPT

This experiment was conducted on mice. Among the many reasons medical researchers use rodents is that they can be genetically-altered ("transgenic mice") to carry genes that are similar to those that cause human diseases. Even without genetic alterations, rodents are widely studied, because they’re biologically very similar to humans and get many of the same diseases.

NAD Supplement NMN Boosts eNAMPT in mice

The Washington University researchers found that a protein abundant in the blood of young mice plays a vital role in keeping mice healthy due to an enzyme this protein creates called eNAMPT. With age, levels of this protein decline in mice and people, while health problems such as insulin resistance, weight gain, cognitive decline and vision loss increases. 

When the researchers gave the older mice the eNAMPT enzyme obtained from younger mice, it: 

  • Boosted NAD fuel production, 
  • The decline in the health of these older mice slowed down, and 
  • Their lifespan increased by about 16%.

"We have found a totally new pathway toward healthy aging," said senior author Shin-ichiro Imai, MD, PhD, a professor of developmental biology. "That we can take eNAMPT from the blood of young mice and give it to older mice and see that the older mice show marked improvements in health - including increased physical activity and better sleep - is remarkable."

Rather than transferring whole blood from young to old mice, as other studies have done, Dr. Imai and his colleagues increased levels of a single blood component, eNAMPT. The impact was dramatic, including improved:

  • Insulin production, 
  • Sleep quality, 
  • Function of photoreceptors in the eye, and 
  • Cognitive function in performance on memory tests, and
  • Running endurance.

Dr. Imai's group also has shown another way to boost NAD levels in tissues throughout the body using NMN supplementation.

If Young Blood's Not Handy, Use NMN

The researchers studied the effects of giving oral doses of a molecule called NMN, a supplement that ProHealth offers in many forms. NMN is the chemical that eNAMPT produces, which conferred the anti-aging health benefits to the mice in Dr. Imai’s study. 

Dr. Imai said:

"We think the body has so many redundant systems to maintain proper NAD levels because it is so important. Our work and others' suggest it governs how long we live and how healthy we remain as we age. Since we know that NAD inevitably declines with age, whether in worms, fruit flies, mice or people, many researchers are interested in finding anti-aging interventions that might maintain NAD levels as we get older."

Imai's research has shown that the hypothalamus is a major control center for aging throughout the body, and it is directed in large part by eNAMPT, which is released into the blood from fat tissue.

 The NAD boosting supplement NMN increases NAD production in the hypothalamus using eNAMPT

The hypothalamus governs vital processes such as body temperature, thirst, sleep, circadian rhythms and hormone levels. The Washington University researchers showed that the hypothalamus manufactures NAD using eNAMPT, which makes its way to the brain through the bloodstream after being released from fat tissue. 

They also showed that this eNAMPT is carried in small particles called extracellular vesicles. As levels of eNAMPT in the blood decline, the hypothalamus loses its ability to function properly, decreasing life span. In fact, levels of eNAMPT in the blood were highly correlated with the number of days the mice lived - more eNAMPT resulted in  longer lifespan, and less resulted in a shorter one.

"We could predict, with surprising accuracy, how long mice would live based on their levels of circulating eNAMPT," Dr. Imia emphasized. "We don’t know yet if this association is present in people, but it does suggest that eNAMPT levels should be studied further to see if it could be used as a potential biomarker of aging."

Whether eNAMPT is a good biomarker of aging in humans, as well as NMN’s impact on increasing eNAMPT levels, may soon be settled. NMN is currently in human clinical trials at Brigham and Women’s Hospital near the Harvard Medical School facility, with initial results projected to be publicized sometime in 2019.

In the meantime, you can do what one of the foremost NMN researchers on the planet does, and begin supplementing with NMN. I refer to Dr. David Sinclair. He and his family liberally supplements with NMN, and although mainly anecdotal at this point, he claims that he and his family are experiencing robust health and increased energy.

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