With so many NMN supplement brand being created to meet the demand for this potent NAD+ precursor, I thought it was high time to collect some data and create an "NMN Review" that compares different brands for dosage, purity and price.
Go straight to the NMN Review »
Over the past few years, research on NAD+ and its precursors, NMN and NR, have given longevity scientists hope that an effective cellular rejuvenator had been discovered. To give you an appreciation for why these scientists are so optimistic, I will:
- Briefly review the science;
- Speak to why we need to keep NAD+ levels up as we age, particularly via NMN; and
List NMN supplement brands are available to you. (See the NMN Review table below.)
NAD+, or nicotinamide adenine dinucleotide, is a coenzyme found in all living cells. Two critical functions enabled by NAD+ make life possible:
- It enables the transfer of energy from the nutrients in the foods we eat to vital cell functions, especially in the brain; and
- It works as a helper molecule for proteins that regulate other biological activity.
Unfortunately, NAD+ levels quickly decline as we age. By age 50 a typical person may have only half the NAD+ they did in youth. By age 80, NAD+ levels drop to only 1% to 10% expressed in youth. 
In 2012, the first study showing this decline examined human skin and established the coenzyme as vital to aging research. In 2015, another human study furthered this proof by showing similar NAD+ decline in the human brain.
The good news is that we can replenish our body’s supply of NAD+ by supplementing with certain molecules that are generally referred to as “precursors”, which is a reference to a series of chemical transformations that creates the NAD+ the body can use.
One of the world’s foremost NAD+ researchers Dr. David Sinclair, Co-director of the Paul F. Glenn Center For The Biology Of Aging At Harvard Medical School says, this about NAD+:
It's one of the most important molecules for life to exist,
and without it, you’re dead in 30 seconds." 
NAD+ precursors like NMN have hit the supplement market like a powerful, unrelenting storm.
There are three obvious reasons for this:
We need NAD+ to live. As mentioned, NAD+, an important coenzyme necessary for our cells to produce the energy that makes our lives possible, declines rapidly as we age. NMN (nicotinamide mononucleotide) and NR (Nicotinamide Riboside) are derivatives of vitamin B3 (niacin) that are converted by your body into NAD+.
We know how to boost NAD+. Many studies on various animal cohorts and humans show that supplementing with NAD+ precursors, such as NMN and NR, boost this vital coenzyme to youthful levels.
- We all desire to live long lives - if they can be healthy - and the evidence indicates that increasing NAD+ can improve brain health, repair damaged DNA and blood vessels, improve autoimmune diseases and more.
Once you’re convinced that the scientific studies showing the health and longevity benefits of NAD+ precursors are sound and have decided to try one, it’s important that you find a source that is:
- Pure and without heavy metal contamination, and
- Readily absorbed into your bloodstream.
With these points in mind, let’s take a look at NMN, beginning with quality assessment, some points about bioavailability (absorption), and then examine various NMN brands available to you in the NMN Review.
Make Sure Your NMN Is Pharmaceutical Grade
The NMN wholesale prices available to buyers like ProHealth range from $600 to $3,500 per kilo (2.2 pounds).
Why such a large difference?
In a word, QUALITY.
There's a very large gap in the quality between the low and high cost NMN available to supplement brands. Mostly, what defines the quality of an NMN supply is:
- Purity, and
Heavy metal content.
We at ProHealth Longevity would love to pay less for our NMN supply, but that would comprise quality. Since quality is paramount, we pay whatever we have to to get NMN that’s pure and contains infetestiminally low amounts of heavy metals. Our Certificate of Analysis by Micro Quality Labs proves the point:
ProHealth Longevity NMN Certificate of Analysis
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Before you buy any brand of NMN, make sure it’s certified to be pure and free of heavy metal contamination. ProHealth’s NMN purity is at 100% and the heavy metals are negligible, as the test certificate above asserts.
How Bioavailable is NMN?
Bioavailability refers to the degree and rate that a drug, supplement, or other substance enters the body's circulatory system when consumed. For example, if 100 mg of a drug are administered orally and 70 mg of this drug are absorbed unchanged within one hour, then the bioavailability is 0.7 or 70% and the rate of complete absorption is one hour.
There has been some debate about the bioavailability of NMN. Like with many drugs or supplements, the issue was centered on whether a sufficient amount of an NMN dose could pass through the gut without being altered by stomach acid. In response to this undesirable possibility, various manufacturers of NMN have endeavored to make NMN products that can survive the stomach, including ProHealth.
ProHealth offers acid resistant and extended release versions of NMN designed to slow and prolong NMN absorption, such as NMN Pro and NMN Pro 250 Extended Release, as well as a sublingual powder called NMN Pro Powder. These are excellent options should you be concerned about bioavailability; however, a 2019 study indicates that NMN is absorbed well, both into the bloodstream and tissues.
Pertinent to NMN bioavailability, the study found that:
"... absorption of NMN from the gut into blood circulation starts within 2–3 min and within 15 min, it is completely absorbed into tissue. Then it is converted and stored immediately as NAD+ in tissues like liver, skeletal muscle, and cortex. This increase in hepatic [liver] NAD+ content persists for about 30 min. After six months of NMN administration, this spiked concentration of NAD+ can be observed in the liver and brown adipose tissue, however, not in skeletal muscle and white adipose tissue."
Given these findings, we can say the following about NMN bioavailability:
- Taking NMN orally will not compromise its passage from the gut into the bloodstream and tissues, as it gets into blood within two to three minutes, and into various tissues within 15 minutes where it’s converted and stored as NAD+.
- Once in the liver ("hepatic") NAD+ persists for 30 minutes.
- Over the course of six months of taking NMN, elevated amounts of NAD+ occurs in the liver and brown adipose tissue.
The bottom line regarding NMN bioavailability is that you most likely need not worry about it. To be on the safe side, however, you can take NMN products made to bypass stomach acids and improve absorption.
Which NMN Product Should You Choose?
The table shows products from various brands, the quantity and dose, and importantly, the price per gram and price per month based on the dose of 250 mg per day. Given that you have to consistently use NMN to benefit from it, knowing what your monthly cost is an important consideration.
As you can see from the table, higher quantities of the powder form offer the lowest monthly cost at the dose of 250 mg per day. We took great effort to ensure that both the lowest priced contender and highest quality NMN is ProHealth NMN Pro Powder 3-Pack (number 6 in the table below).
-- A Product Comparison --
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* Higher relative prices are due to the small amount of NMN per capsule in these products.
Prices and information verified as of 5/30/19
(Read, The 8 Most Important Things You Need to Know About NMN.)
To sum up, I hope you now have a better understanding of how important NAD+ is to your health and longevity. The bottom line is that life cannot exist without NAD+ and it declines in our body as we age.
NMN is a proven way to boost your NAD+ level. Go here and check out our wide variety of NMN supplements and select the one that best fits your needs.
Joe Garma has written more than 670 articles on his anti-aging blog, GarmaOnHealth, and is currently writing a book, The Ageproof Method, 12 Biohacks for A Long and Strong Life. Prohealth Longevity readers can get his four-part guide, Transform Your Body and Mind here.