The Magnificent Mineral Magnesium: How Brain-Mag Pro (Magtein®) Supplements May Support Memory, Mood, and Cognition With Age

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The Magnificent Mineral Magnesium: How Brain-Mag Pro (Magtein®) Supplements May Support Memory, Mood, and Cognition With Age

From mood regulation to memory support to metabolism, magnesium is involved in many of our body’s and brain’s most essential processes. But, most people don’t get nearly enough of this essential mineral.

As agricultural practices have depleted soil magnesium in recent years, which reduces the amount found in plant foods, and magnesium supplements tend to have low bioavailability, it’s estimated that up to 80% of Americans are lacking or deficient in this mineral. Older adults are especially susceptible to magnesium deficiency, and many researchers link this inadequacy to one of the leading health problems facing aging adults: cognitive decline.

To combat these issues, some companies are searching for the best form of supplemental magnesium to boost both absorption and brain health — and the answer may be magnesium L-threonate, found in the supplement Brain-Mag Pro (Magtein®).

This form of the mineral is considered superior for brain health, as it is readily absorbed and can cross the highly selective and protective blood-brain barrier that protects the brain from pathogens and other harmful compounds. Let’s take a closer look at how magnesium threonate supports brain health and cognition with age.

The Brain-Boosting Benefits of Brain-Mag Pro (Magtein®)

Due to magnesium L-threonate’s ability to cross the blood-brain barrier, which is essential for a supplement to directly affect cognition, Brain-Mag Pro can rapidly increase levels of the mineral in the brain. This leads to several brain-boosting benefits, including improved memory and mood, delayed cognitive impairment, and better communication between brain and nerve cells. 

Sparking New Neural Connections Supports Cognition

Magnesium threonate is essential for maintaining between-cell signaling and promoting the growth, maturation, and survival of both neurons and their networks. Because of these functions, magnesium threonate is linked to preserved synaptic plasticity — how flexible and adaptable the brain is to forming new connections. Similarly, magnesium threonate boosts the production of brain-derived neurotrophic factor (BDNF), a protein that promotes the survival and growth of neurons.

In a study with animals, magnesium threonate was found to increase the density of synapses — connections between nerve cells — in the hippocampus, the region of the brain most responsible for learning and memory. Plus, mice who received this supplement also had a reduced buildup of amyloid-beta plaques, which are characteristic of Alzheimer’s disease development, and showed a reversal of cognitive deficits.

As synaptic dysfunction is a leading cause and predictor of cognitive decline, focusing on preserving these signaling pathways via adequate magnesium threonate intake may help to prevent or slow down the progression or development of dementia.

Researchers have also looked at how Magtein® works in humans. In a controlled trial published in the Journal of Alzheimer’s Disease, 44 older adults with cognitive impairment were randomized to take between 1.5 to 2 grams of magnesium threonate per day (depending on their body weight) or a placebo for 12 weeks. They found that those taking Magtein® experienced significantly improved cognitive ability and memory.

Not only that, but magnesium threonate reduced their overall brain age by nine years, as measured by tests of executive function — the set of mental skills that include working memory, flexible thinking, and self-control. We use these skills every day to learn, work, and manage daily life. Declines in executive function can make it hard to focus, follow directions, and handle emotions, which are all symptoms of Alzheimer’s disease and dementia.

Magnesium threonate is essential for maintaining between-cell signaling and promoting the growth, maturation, and survival of both neurons and their networks.

Magtein® Makes Moves on Mood Disorders

Magnesium also plays a role in mood disorders, such as depression, likely due to its previously mentioned role in neuronal signaling and BDNF production. Plus, magnesium threonate is involved with the function of some neurotransmitters — chemicals made by neurons that specifically transmit messages to other cells. 

One neurotransmitter that magnesium impacts is GABA (gamma-aminobutyric acid), which is an inhibitory neurotransmitter, in that it blocks or decreases specific brain signals. Although blocking brain signals sounds negative, GABA’s ability to reduce nervous system activity leads to feelings of calmness and can lower anxiety or stress. Magnesium threonate also helps to regulate the synthesis of other mood-boosting neurotransmitters like serotonin and dopamine.

Lastly, magnesium threonate may improve mood by preventing an over-stimulation of glutamate — an excitatory neurotransmitter. With opposing functions of GABA, too much glutamate leads to neuronal cell death and is linked to depression and psychiatric disorders like schizophrenia.

In a recent study, older adults with lower blood magnesium levels were significantly more likely to score higher on measures of depression, even when magnesium levels were technically within the normal range. This suggests that even without a full-blown deficiency, magnesium levels on the lower end of adequacy — which is increasingly common among older adults — may be implicated in mood disorders. However, magnesium threonate has not been studied in humans to determine its direct effects on depression or other mood disorders yet.

Key Takeaway: 

  • While there are many forms of supplemental magnesium, Brain-Mag Pro (Magtein®) in the form of magnesium L-threonate is best suited for supporting brain health, memory, and cognition with age. 
  • As the majority of Americans, and especially older adults, consume low amounts of magnesium or experience low bioavailability of typical supplements, Brain-Mag Pro mitigates these issues by providing a highly absorbable form of magnesium threonate that can cross the blood-brain barrier and boost brain magnesium levels rapidly.
  • Studies in animals and humans have found that magnesium threonate supplementation is linked to improved memory, executive functions, cognition, synaptic plasticity, and mood.

Show references

Li W, Yu J, Liu Y, et al. Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer's disease mouse model. Mol Brain. 2014;7:65. Published 2014 Sep 13. doi:10.1186/s13041-014-0065-y

Liu G, Weinger JG, Lu ZL, Xue F, Sadeghpour S. Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. J Alzheimers Dis. 2016;49(4):971-990. doi:10.3233/JAD-150538

Tarleton EK, Kennedy AG, Rose GL, Crocker A, Littenberg B. The Association between Serum Magnesium Levels and Depression in an Adult Primary Care Population. Nutrients. 2019;11(7):1475. Published 2019 Jun 28. doi:10.3390/nu11071475

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