What is Agmatine Sulfate?
Agmatine sulfate is a common amino acid derived from L-arginine that’s involved in protein synthesis. When L-arginine undergoes decarboxylation, a process that results in the removal of a carboxylic acid group, it converts into agmatine sulfate. Agmatine sulfate is stored in neurons within the brain and gets released when those neurons are activated.
Agmatine sulfate is regarded as a neuromodulator and neurotransmitter which may explain some of the Agmatine sulfate nootropic benefits some people tend to experience. As a nootropic, Agmatine sulfate offers a diverse profile of potential Agmatine sulfate benefits for brain health and function as well as overall fitness.
Agmatine Sulfate Benefits and Uses
- May help promote positive emotional outlook*
- May help support restful sleep*
- May help promote immune system function*
- May help promote strength and endurance*
- May help support gastric motility and digestion*
- May help support cognitive function*
- May help promote cardiovascular function*
Agmatine Sulfate Bodybuilding and Nootropic use
Agmatine benefits may involve an array of organs and bodily systems to help promote overall health. Agmatine sulfate’s interaction with NMDA and Nitric oxide receptors have been shown to promote several elements of cognitive function and brain health. In particular, these results focused heavily on memory and learning abilities. Research on Agmatine benefits on animals uncovered Agmatine sulfate’s ability to support healthy oxidation levels. It is believed that this may be a result of Agmatine’s capacity to limit glutamate activity. High glutamate activity can potentially induce over-excitation in the brain. This over-excitation is known as excitotoxicity. Excitotoxicity can cause nerve cells to degrade due to being overactivated.
As far as how this translates to Agmatine sulfate nootropic effects, Agmatine seems to interact with a few neurotransmitter pathways and systems. When it comes to glutamate receptors, studies found that Agmatine appears to act strongly on these receptors and pathways. Research has found that Agmatine levels tend to increase in some regions of the brain when engaged in a learning process. Agmatine even appeared to exert some influence in memory formation in these areas. Taking an Agmatine supplement may help support memory formation events which may increase overall cognitive function with an emphasis on learning and memory.
Agmatine has also forged a reputation in the bodybuilding community for its ability to create massive muscle pumps via its Nitric oxide regulation. Nitric oxide is a compound that’s naturally produced in our bodies and plays an important role in cell signaling and communication throughout the entire system. Anecdotal reports suggest that this enhanced connection may also promote feelings of well being. Agmatine sulfate is highly utilized as a main ingredient in various pre-workout formulas and “pump” supplements. In fact, it’s very common among bodybuilders to pair a pre-workout with agmatine sulfate.
Some athletes swear by the agmatine sulfate bodybuilding benefits. As if boosting Nitric oxide levels and promoting cognitive function weren’t enough agmatine benefits for you, Agmatine sulfate also appears to support blood flow by behaving as a calcium antagonist. Research has found that this interaction may help widen and soothe blood vessels which in turn may support overall cardiovascular function. What’s even better, is that Agmatine may help create lean muscle mass and may even promote muscle definition. This makes Agmatine sulfate one of the best muscle pump supplements out there!
How Agmatine Sulfate May Promote Cognitive Function
Agmatine sulfate also appears to interact with NMDA glutamate receptors. When these receptors get activated, they allow ions with a positive charge to pass through cell membranes. NMDA receptors are also one of the major glutamate receptors involved in regulating synaptic plasticity and memory functions. Synaptic plasticity is important for the ability of signals between nerves to strengthen or weaken over time. A healthy level of synaptic plasticity means signals are more effectively communicated between neurons.