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Life Extension

5-LOX Inhibitor with ApresFlex® (100 mg, 60 vegetarian capsules) by Life Extension

SKU: N1151

$16.50

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Description

5-lipoxygenase (5-LOX) is a member of the lipoxygenase family of enzymes. It transforms fatty acids into leukotrienes. Excess levels of the enzyme 5-LOX sets in motion inflammatory responses that have been linked to common effects in aging individuals.1-5 Normal aging results in higher-than-desired levels of 5-LOX. The typical American diet adds to the danger. Foods rich in omega-6 fatty acids like red meat, poultry, eggs and dairy products, along with high-glycemic carbohydrates, trigger overproduction of arachidonic acid. In response to high levels of arachidonic acid, the body produces the 5-LOX enzyme.

Supplement Facts
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Servings Per Container: 60
Amount Per Serving %DV
AprèsFlex® (Boswellia serrata) extract (gum resin) [std. to 20% 3-O-acetyl-11-keto-B-boswellic acid (AKBA) (20 mg)] 100 mg **
** Daily Value not established.
ApresFlex® is a registered trademark of Laila Nutraceuticals exclusively licensed to PL Thomas – Laila Nutra LLC. U.S. Patent No. 8,551,496 and other patents pending.
  • Suggested Use:To inhibit the 5-lipoxygenase enzyme, take one (1) capsule daily with or without food, or as recommended by a healthcare practitioner.
  • Storage: Store in a cool dry place. Keep out of reach of children.
  • Contraindications: When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating. Do not exceed recommended dose.
  • Other Ingredients: microcrystalline cellulose, vegetable cellulose (capsule), silica, vegetable stearate.

5-LOX breaks down arachidonic acid to pro-inflammatory compounds like leukotriene B4,6 a molecule that mediates attacks to joints, arterial walls, and other tissues. 5-LOX itself modulates undesirable cell division changes.7,8

The good news is that an extract of the Indian plant Boswellia serrata has been shown to neutralize 5-LOX. Used for centuries to help with inflammatory factors, boswellia acts as a natural 5-LOX inhibitor, intervening at the cellular level to block its unwanted effects. Confirmatory data reveal that a compound contained in boswellia called AKBA (3-O-acetyl-11-keto-ß-boswellic acid)9,10 is the key to its beneficial action.

The problem is that boswellia is poorly absorbed into the blood.11 For this reason, a patent-pending, standardized form of boswellia called AprèsFlex® is being introduced. AprèsFlex® absorbs into the blood 52% more than previously available boswellia extracts.11

Each 100 mg vegetarian capsule of 5-LOX Inhibitor with AprèsFlex® is standardized to provide 20% of active AKBA from boswellia. Most people need only one capsule a day.

*These statements have not been evaluated by the Food and Drug  Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Individual results may vary.

References:

  1. Neurobiol Aging. 2007 Sep;28(9):1457-62.
  2. Cardiovasc Psychiatry Neurol. 2009;2009:174657.
  3. Free Radic Biol Med. 2009 Jul 1;47(1):62-71.
  4. Rejuvenation Res. 2009 Feb;12(1):15-24.
  5. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Mar 30;35(2):315-9.
  6. Curr Opin Investig Drugs. 2009 Nov;10(11):1163-72.
  7. Carcinogenesis. 2006 Sep;27(9):1902-8.
  8. Clin Cancer Res. 2005 Mar 1;11(5):2089-96.
  9. Wien Med Wochenschr. 2002;152(15-16):373-8.
  10. J Ethnopharmacol. 2006 Sep 19;107(2):249-53.
  11. Mol Cell Biochem. 2011 Aug;354(1-2):189-97.