Activated B-12 Guard™ (2000 mcg, 100 Lozenges) by Perque Integrative Health

SKU: N037



Optimal B-12 Delivery to the Brain

  • Provides nearly the same B-12 uptake as from injection
  • Superior, activated form of B-12: hydroxocobalamin
  • Promotes hearth health and fights fatigue
Supplement Facts
Supplement Facts
Serving Size: 1 Sublingual Lozenge
Servings Per Container: 100
Amount Per Serving %DV
B-12 (hydroxocobalamin) 2,000 mcg 33,330%
Mannitol 295 mg *
Organic, whole cane juice 1 mg *
100% Whole cherry fruit extract 3.5 mg *
Raspberry flavor 8.5 mg *
Croscarmellose Sodium 25 mg *
Magnesium (as C16 and C18 alkyls†) (†from whole, untreated palm fruit and leaf) 3.5 mg *
Percent Daily Value based on a 2000 calorie diet.
* Daily Value not established by FDA
Note: Do not use product if the tamper-resist shrink band around the cap or the inner seal beneath the cap appears to have been tampered with or is missing.
  • Suggested Use: As a dietary supplement, take one (1) sublingual lozenge daily or as directed by your health professional. Place lozenge under tongue and let dissolve.
  • Storage: Must be stored with cap on tightly in a cool, dry place. Keep out of reach of children.
  • Contraindications: Pregnant and nursing mothers need to check with their health professinal before taking supplements.
  • Other Ingredients: None.
  • Contains No: Citrus, MSG, wheat, gluten, corn, starch, sugar, wax, soy, yeast, zein, sulfate, phosphates, (other than coenzymes), preservatives, casein or other milk derivatives. No GMOs.s

Perque Activated B-12 Guard is in lozenge form for maximum uptake and optimal delivery to the brain. Studies on Perque Activated B-12 Guard lozenge formulation show nearly the same B-12 uptake as from injection. Patients notice that they feel better more quickly.*

Vitamin B-12 in our food supply is estimated to be 78% less than in the 1960s. Diet alone is hard pressed to provide the necessary levels of this important nutrient. In addition, stress and reduced hydrochloric acid (HCl) and intrinsic factor production in the stomach impair absorption. The most commonly used forms of B-12 require activation in the body, making uptake quite low - rarely more than 50%.*

Perque delivers vitamin B-12 in its superior, activated hydroxocobalamin form. Hydroxocobalamin lasts longer and raises B-12 blood concentrations higher than other forms. Hydroxocobalamin requires no intrinsic factor and is taken up directly by mucous membranes regardless of digestive competence.* Hydroxocobalamin is easily converted to active but short-lived methylcobalamin and adenosylcobalamin as needed in the body. Hydroxocobalamin, the parent to other B-12 forms, provides better, long-lived B-12 action in the body.

erque Activated B-12 Guard is one of the supplements included in the Simplified Methylation Protocol for chronic fatigue syndrome (ME/CFS) and fibromyalgia that was developed by Drs. Neil Nathan, MD; Rich Van Konynenburg, PhD; Amy Yasko, PhD; and Jacob Teitelbaum, MD. This group of supplements (FolaPro, ActiFolate, Perque Activated B-12 Guard, and Neurological Health Formula) has been selected and formulated to provide nutrients that the body needs to support normal methylation - a process that is critical for a host of the body's most important chemical reactions, from creation of glutathione (the body's 'master' antioxidant and detoxifier) to energy generation, DNA repair, and serotonin production.

Doses used in the Simplified Methylation Protocol trial* are as follows:

Actifolate: 1/4 tablet (200mcg) daily [60 tablets in bottle]

Folapro: 1/4 tablet daily [60 tablets in bottle]

General Vitamin Neurological Health Formula: Start with 1/4 tablet and work up, very slowly, to 2 tablets daily [180 tablets in bottle]

Activated B-12 Guard: 1 sublingual lozenge daily [100 tablets in bottle]

Note: As Dr. Nathan's trial report suggests, another supplement considered beneficial but not central to the protocol is phosphatidyl serine.

Activated B-12 Guard for SAMe

Optimal absorption of vitamin B-12 is essential to keep SAMe (S-adenosyl methionine) in its beneficial form. SAMe is critical for the manufacture of brain chemicals and for detoxification.*

Promotes Heart Health

The correlation between homocysteine (an amino acid that at elevated levels in the body may indicate an increased risk of cardiovascular disease) and vitamin B-12 is significant. Nearly 57% of men with elevated homocysteine have low levels of B-12. Signs of deficiency may take as long as six or more years to manifest clinically. Meanwhile, as homocysteine levels climb, cardiovascular risk rises. B-12 Guard, taken with the synergistic nutrients B-6 and folic acid, delivers maximum action for keeping homocysteine levels low.*

Fights Fatigue

Hectic lifestyles, stress, and increasing levels of toxins in the environment can lead to exhaustion. Individuals suffering from fatigue can benefit from B-12 supplementation. B-12 stimulates the body's utilization of proteins, fats, and carbohydrates, which in turn can increase energy. Research shows that 2-20 mg. (2,000 - 20,000 mcg) daily is required for optimal benefit. Each B-12 Guard lozenge delivers 2,000 mcg of B-12.*

More About Homocysteine and B-12

The importance of maintaining normal homocysteine levels cannot be overemphasized. Your heart health depends on it. Clearly, the scientific evidence indicates that nutrient deficiency is a factor in elevated homocysteine levels. However, in a recent study, researchers discovered that in many patients, even when serum levels of vitamins appear to be normal, homocysteine concentrations were still too high.*

Elevated homocysteine levels are implicated in much more than heart disease. In a study of women with both chronic fatigue syndrome and fibromyalgia, researchers discovered that all of the patients had high levels of homocysteine in their cerebrospinal fluid. They also noted a significant correlation between high homocysteine levels and fatigue. The study emphasized the importance of the relationship between B-12 and homocysteine, and showed that B-12 deficiency was a contributing factor. By decreasing levels of homocysteine in the central nervous system, B-12 can help prevent and treat fatigue.*

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat or prevent any disease.