TMG Pro Tablets (1000 mg, 120 tablets) by ProHealth Longevity

SKU: PH568



A Methyl Donor That Complements NMN Supplementation

  • Supports cardiovascular health*
  • Promotes healthy homocysteine levels*
  • Helps replenish the body's methyl pool*

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Supplement Facts
Supplement Facts
Serving Size: 1 Tablet
Servings Per Container: 120
Amount Per Serving %DV
Trimethylglycine (TMG) (Betaine Anhydrous) 1 g (1,000 mg)
† Daily Value not established
  • Other Ingredients: Cellulose, Stearic Acid (vegetable source), Croscarmellose Sodium, Magnesium Stearate (vegetable source) and Vegetarian Coating.
  • Not Manufactured With: Milk, egg, soy, gluten, wheat, fish, shellfish or tree nut ingredients.
  • Suggested Daily Use: Take 1-6 tablets daily, divided into 2 doses, or as recommended by your healthcare provider. If you have trouble swallowing large tablets, it is recommended that you cut or chew these tablets before swallowing.
  • Note: Keep the bottle tightly closed at all times in between usage. Keep the freshness packet in bottle. This product is very sensitive to moisture/humidity which may affect product stability. Store in a cool dry place after opening.
  • Caution: Consult physician if pregnant/nursing, taking medication, or have a medical condition.

Trimethylglycine (TMG), also known as betaine anhydrous, is an amino acid that supports the body's methylation processes. Methylation is a fundamental biochemical process in which one carbon atom and three hydrogen atoms (CH3) are transferred from one molecule to another. This process is responsible for numerous important bodily functions, such as:

  • Cell division
  • Cellular energy production
  • Clearing histamine
  • Metabolism
  • DNA expression (epigenetics)
  • Forming neurotransmitters
  • Producing free radical scavenging antioxidants

Our bodies contain a “methyl pool” of CH3 that is available whenever needed. As long as we have enough methyl groups stored in the pool, methylation typically is not a problem. However, there are a couple of things that may contribute to the depletion of the body's methyl pool.

  1. MTHFR Variants - Methylenetetrahydrofolate reductase (MTHFR) is a gene with common mutations that can interfere with the methylation process, causing high levels of homocysteine (a known risk factor in heart disease) in the blood and low folate levels. Up to 40% of the population may have one or both genetic mutations.

  2. Aging and Epigenetics - Methylation of DNA plays a crucial role in epigenetics, switching different sequences of your genetic material on and off as needed. The body's methylation ability and subsequent DNA expression is known to decline with age. Anti-aging researchers think these changes in DNA expression may be a contributing factor to many age-related diseases.*

NMN Supplementation and Methylation Support

When taken as a supplement, NMN may require the use of methyl groups to help facilitate the conversion of NAD+ in your cells, thereby activating sirtuin genes and promoting longevity. Although there is currently no evidence suggesting NMN’s natural methylation process depletes the methyl pool, many top anti-aging experts suggest that safeguarding against methyl depletion may be a wise proactive step to augment your NMN intake. TMG, the choice of many of those experts, is an excellent way to help support your body's ability to maintain an adequate methyl pool.

Customer Reviews

Based on 19 reviews
Frank M.
Younger with every minute

Wow! Wunderpills a la Sinclair. You take them and you feel within days younger and more beautiful. With a high sex appetite like in younger years. Strongly recommended.

Jacque M.
Noticed clear thinking and energy

I have had no side effects TPG pro. The tablets are large for me so cut in half. Use with nmn and reservertrol and feel good.

William W.
A useful tool in the kit

I take ProHealth Longevity TMG as a methyl provider with NMN and I also take one before bed, as it has a very calming effect that lasts through the night. I used to wake up several times a night and find it hard to drift off again, but that’s all in the past since I started taking TMG.

i guess its good if it works

who knows... if i live longer than I would have then it worked


TMG Pro Tablets

Rebecca N.

Feel great after taking these.

David C.
Good value

Tablet size ok to take .. not too large
Good value
Start taking for the first month .. will review after a few months

Steven S.

Been ordering a lot online lately and ProHealth has been really impressive logistically— effortless & efficient.
Still in the early days of using the products, so need more time to give meaningful feedback in that regard.

Alessandra M.
Excellent product!

Been ordering for about a year now and it’s part of my daily routine.


TMG Pro Tablets (1000 mg, 120 tablets) by ProHealth Longevity