Theacrine (1,3,7,9-tetramethyluric acid) is found in some coffee species and tea, most notably kucha (Camellia assamica). Theacrine (TeaCrine®) Capsules Mode of Action
TeaCrine® is a chemically equivalent version of theacrine. Theacrine is an alkaloid molecule closely related to caffeine but structurally different. The most abundant source of theacrine known at this time is from Kucha tea leaves.
The difference between theacrine and caffeine molecules is an additional methyl group and ketone group. Like caffeine, theacrine causes signaling changes on adenosine receptors and may influence dopaminergic signaling in a similar manner to caffeine.
Kucha tea is a Chinese tea containing two major alkaloids, caffeine and theacrine. Concentrations of both alkaloids are higher in younger leaves and buds and lower in mature leaves. Research suggests that theacrine is synthesized from adenosine through caffeine in a three-step pathway within the kucha leaves.
Unlike caffeine, no adverse effects or changes in blood pressure or heart rate occur in animal studies. Even when combined with caffeine, no differences in heart rate or blood pressure were noted in human trials. In a clinical human study, all values for clinical safety markers (such as blood pressure, heart rate, lipid profiles, biomarkers of liver, kidney, and immune function, and hematologic blood counts) were normal throughout the 8-week study.
TeaCrine® was found to be non-habituating, unlike caffeine
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*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.