Caloric restriction and intermittent fasting are known to prolong life- and healthspan in model organisms. In a randomized controlled trial, 4 weeks of strict alternate day fasting improved health markers in middle-aged humans.

Progressive arterial stiffness causes a state of chronically high blood pressure, which can lead to cognitive decline by damaging sensitive tissues in the brain and other organs.

Epigenetic reprogramming holds out great hope for making aging cells youthful again. But since it doesn't address the underlying damage, many scientists are waving red warning flags.

Today's open access paper is a review of present progress towards regenerative therapies that can reverse hearing loss. Progressive hearing loss is pervasive in old age, and accelerates considerable in the later stages of life. Hearing loss correlates with cognitive decline, and while it is plausible that this is because of degeneration of central nervous system function, there is also the consideration that loss of hearing isolates people and deprives them of interactions that stimulate brain activity. It is well demonstrated in mice that environment richness has a strong impact on the brain and its pace of aging. Much of...