Why The Best Resveratrol Supplement Is Trans-Resveratrol

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Why The Best Resveratrol Supplement Is Trans-Resveratrol

Resveratrol, long touted for its many health benefits, has recently come to the forefront again thanks to Harvard geneticist and anti-aging researcher David Sinclair, who famously combines 1,000 mg of NMN powder and between 500 and 1,000 mg of resveratrol into his yogurt each morning. What is resveratrol and why is important for longevity?

Resveratrol is a stilbenoid, a type of natural phenol, which is mildly toxic and produced by numerous plants in response to ultraviolet radiation, injury, fungal, or bacterial infection. Resveratrol is concentrated in the skin and the seeds of these plants. Currently, there are 162 clinical trials involving this compound, futher highlighting its recent rise in popularity.  

Research has shown that resveratrol may help promote lifespan extending effects and alleviate metabolic diseases through its activation of sirtuins, the so-called "longevity genes." Sirtuins are genes that regulate cellular health and protect the body from deterioration and disease.

But there's a problem with resveratrol — all of the therapeutic benefits attributed to it are encumbered by its low bioavailability. In other words, most forms of resveratrol supplementation are not well absorbed by your body, and therefore, its potential health benefits are blunted.

But the good news is that researchers have focused on designing and synthesizing derivatives of resveratrol to enhance the body's ability to absorb it and increase its therapeutic activity. One of these is trans-resveratrol; it has been demonstrated to get into your bloodstream quicker and linger longer. 

Why The Best Resveratrol Supplement is Trans-Resveratrol

Of the various types of chemical structures that make resveratrol, the main one that confers many of the health benefits in resveratrol studies is called trans-resveratrol, but the type of reseveratrol found in most supplements is known as cis-resveratrol. Indeed, regular resveratrol is composed of 50% trans-resveratrol and 50% cis-resveratrol.

Research suggests that only the trans- form has valuable biological activity, whereas regular resveratrol is notoriously difficult for the body to utilize because it is poorly absorbed. 

Trans-resveratrol is superior over regular resveratrol:

  • Trans-resveratrol inhibits memory loss and mood dysfunction, which can occur during aging.
  • Trans-resveratrol contains more cardioprotective properties than regular resveratrol.
  • Trans-resveratrol may exhibit antiviral properties against a variety of viruses compared to regular resveratrol.
  • Trans-resveratrol is more readily absorbed in comparison to regular resveratrol.

Therefore, the best resveratrol supplement you can take is trans-resveratrol simply because more of it gets into your bloodstream where it can potentially provide many health benefits. That said, when combined with BioPerine®, a black pepper derivative, it further enhances the bioavailability of trans-resveratrol. 

Why The Best Resveratrol Supplement Contains BioPerine®

One 2016 study, examined the effects of resveratrol and piperine supplementation in combination with exercise training on the muscle mitochondrial capacity of the forearms of sixteen healthy, young adults. The volunteers were given pills containing placebo or a resveratrol (500 mg) and BioPerine® (10 mg) combination for four weeks. All participants performed three sessions of sub-maximal endurance training of the wrist flexor muscles of the non-dominant arm every week. The researchers concluded:

"Low-intensity exercise training can increase forearm skeletal muscle mitochondrial capacity when combined with resveratrol and piperine supplementation."

Clearly, supplementation with resveratrol and BioPerine® combination improves the bioavailability of resveratrol, and could prove useful in enhancing skeletal muscle mitochondrial capacity during low-intensity exercise training.

The Fabulous Duo: Trans-Resveratrol + BioPerine®

You'd be hard pressed to find a supplement that contains both trans-resveratrol and BioPerine®. We couldn't find one that we liked, so we made our own:

1000 mg Trans-Resveratrol.

Our trans-resveratrol supplement contains:

  • 1,000 grams of trans-resveratrol
  • A proprietary blend of 400 of organic quercetin, organic red wine extract, organic decaffeinated green tea extract, and BioPerine®

As you've already learned, the trans-resveratrol improves the potential health benefits of regular resveratrol by making it more bioavailable, which is further enhanced by BioPerine®. We include organic quercetin in the formula for its antioxidant and anti-inflammatory effects, organic red wine extract at 50% polyphenols to enhance the health benefits conferred by trans-resveratrol, and decaffeinated organic green tea extract with 30% polyphenols for its catechin content, which are antioxidants that fight and may even prevent cell damage.

All of these ingredients contained in ProHealth's 1000 mg Trans-Resveratrol are potent polyphenols. Antioxidant-rich polyphenols may play an important role in preventing and reducing the progression of diseases like diabetes and neurodegenerative and cardiovascular conditions. They also may be a helpful prebiotic that increase the number of beneficial bacteria in your gut, important for health, weight management, and disease prevention.

And there's more good news for NMN enthusiasts: NMN and resveratrol work synergistically to activate the sirtuin genes. They have been likened to the operation of a car, with NMN as the fuel and resveratrol as the accelerator pedal. Taken together, NMN and resveratrol are the dynamic duo of longevity supplements.

Your Takeaway

Remember these four things:

  1. Resveratrol has been extensively tested and is deemed safe for most people, although it could interact with certain medications. Check with your doctor before taking resveratrol.
  2. Trans-resveratrol is better than regular resveratrol due to its superior bioavailability; in fact, many studies that show the health benefits derived from resveratrol is actually testing trans-resveratrol.
  3. The well-documented absorption capabilities of trans-resveratrol is enhanced further by combining it with BioPerine®.
  4. Trans-resveratrol can be combined with NMN for a disease-fighting combo that promotes cellular health and protects the body from deterioration. 
Show references

Find a Study. ClinicalTrials.gov website. https://clinicaltrials.gov/ 

Kuršvietienė L, Stanevičienė I, Mongirdienė A, Bernatonienė J. Multiplicity of effects and health benefits of resveratrol. Medicina. 2016; 52(3): 148-55. doi: 10.1016/j.medici.2016.03.003

Johnson JJ, Nihal M, Siddiqui IA, et al. Enhancing the bioavailability of resveratrol by combining it with piperine. Molecular Nutrition & Food Research. 2011 August ; 55(8): 1169–1176. doi:10.1002/mnfr.201100117

Polley KR, Jenkins N, O'Connor P, McCully K. Influence of exercise training with resveratrol supplementation on skeletal muscle mitochondrial capacity. Applied Physiology, Nutrition, and Metabolism. 2016 Jan; 41(1): 26-32. doi: 10.1139/apnm-2015-0370

Smoliga JM, Baur JA, Hausenblas HA. Resveratrol and health--a comprehensive review of human clinical trials. Molecular Nutrition & Food Research. 2011 Aug; 55(8): 1129-41. doi: 10.1002/mnfr.201100143

Weiskirchen S, Weiskirchen R. Resveratrol: How Much Wine Do You Have to Drink to Stay Healthy? Advances in Nutrition. 2016 Jul 15; 7(4): 706-18. doi: 10.3945/an.115.011627


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