Bulletproof Your Mitochondria Function With MitoQ

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Bulletproof Your Mitochondria Function With MitoQ

All living things are made up of cells, the smallest structural and functional unit of an organism. And all cells are powered by an organelle inside them called mitochondria, the so-called "energy factory".

Without functional mitochondria you would die within a few minutes, says David Wynick, Professor of Molecular Medicine at the University of Bristol. This is because these free-floating, bean-shaped organelles that live in almost every cell of our body generate more than 90% of the energy needed by our bodies to sustain life and promote growth.

All cells have organelles within them that enable mitochondria function

I'm going to tell you more about how essential robust mitochondria function is to your health and vitality - especially if you seek to extend your healthspan - but first let's get right to the point of this article:

The health of your mitochondria degrades as you age (mainly via free radical damage), but you can neutralize excessive free radicals by a highly absorbable form or Coenzyme Q10 (CoQ10) called MitoQ®.

You'll learn just how MitoQ® does this in a moment, followed by:

  • What are mitochondria and why are they essential;
  • How free radicals damage your mitochondria;
  • How mitochondria impacts aging; and
  • Which MitoQ formula is right for you.

Let's dig in, beginning with a look at how valuable MitoQ® supplementation is to your mitochondria health.

How MitoQ® Supports Healthy Mitochondria Function

MitoQ can support mitochondria functionAs you've learned, the mitochondria can use some help fighting off the damaging free radicals, especially as we get older, and MitoQ®, a potent form of CoQ10, is a proven ally.

MitoQ® is a shortened form of the antioxidant ubiquinol (CoQ10), made by the addition of an ion called Triphenylphosphonium, which gives it a positive charge. These modifications allow MitoQ® to pass through the mitochondrial membrane where it then provides a payload of free radical defense right where it's needed most and at concentrations several hundred-fold higher than if it just stayed in the blood.

As it helps to neutralize excessive free radicals, MitoQ® stabilizes the mitochondrial membrane, protecting it from subsequent free radical attack. When taken in conjunction with a healthy diet and regular exercise MitoQ® helps support your body against oxidative stress and the body's defenses against degenerative health conditions.

This four-minute video tells the tale:

 

MitoQ, the company, suggests that you:

    • Try MitoQ® 5 mg for a minimum of three months to give the product time to make a meaningful difference.
    • Take it either at least 30 minutes before, or two hours after eating, because the absorption of MitoQ® is significantly impaired if taken with food.
  • Take the recommended dose is 10 mg per day. MitoQ®has been taken in doses as high as 80mg a day for a year during safety testing, but that much is unnecessary.

Watch Masters' triathlete Darrah Walsh describe how MitoQ helped him create the sustained energy he needed to stay competitive as he aged:

 

This happens through a process known as cellular respiration. During cellular respiration, the function of mitochondria is to produce the energy currency of the cell by releasing energy from the food we eat and the oxygen we breathe (called ATP, or Adenosine Triphosphate) and to regulate cellular metabolism.

Healthy mitochondria function is essential to your good health. The problem is that our mitochondria degrades and gradually becomes less functional as we age, mainly due to free radical damage. That's the bad news. The good news, as you've just learned, is that you can do something about this by regularly using MitoQ®.

Next up a review of why you want your mitochondria to function as optimally as possible.

What Are Mitochondria and Why Are They Essential?

cellular energy requires robust mitochondria function

Mitochondria are free-floating, bean-shaped organelles that live in almost every cell of our body. They generate more than 90% of the energy needed by our bodies to sustain life and promote growth. Cells that require the most energy - such as those in the brain, heart, skeletal muscles, and the eye - contain the most mitochondria.

Although their role in converting food and oxygen into fuel is essential for life, our mitochondria does much more, says MitoQ's website page on mitochondria function and dysfunction. For instance, they also:

  • Are involved in the manufacture of DNA, hemoglobin, estrogen and testosterone.
  • Help metabolize cholesterol and produce antioxidants, like CoQ10, which neutralize free radicals and decrease oxidative stress.
  • Are the only separate structure in the cell to have their own DNA, giving them the ability to self-replicate and increase their numbers if the cell requires more energy, such as during growth or intense exercise.
  • Help the cell perform specialized functions. For example, mitochondria in liver cells allow the cell to breakdown toxic ammonia into harmless urea which is then excreted.

So now that you have a good sense of how vitally important are healthy functioning mitochondria, a reasonable question is:

"How vulnerable are we to impaired mitochondrial function?".

A good place to begin to seek an answer to that question is with the Mitochondrial Free Radical Theory of Ageing (MFRTA). It suggests that health and longevity comes down to well-performing mitochondria and well-controlled rates of free radical production, both of which are easily damaged by many factors.

Support for this theory is found in studies on long-lived animals which show low rates of free radical production and mitochondrial and cellular membranes relatively resistant to free radical attack. The MFRTA offers an explanation for longevity variation among different animal species that is not related to size, shape, or cognitive ability.

Unfortunately, mitochondria are easily damaged by exposure to environmental toxins and excessive free radical production. In addition, dietary deficiencies or genetic mutations can also disrupt how your mitochondria function. All this is very problematic for healthy mitochondria function, as we'll examine next.

How Free Radicals Damage Your Mitochondria

free radicals impair proper mitochondria function

Environmental toxins such as pollution, industrial chemicals, cigarette smoke, and UV radiation damage delicate mitochondria. Diets lacking certain vitamins or minerals or high in trans fats, sugar, burnt or processed meats increase free radical production and exhaust our natural antioxidant supply.

As explained by MitoQ, this is how free radicals damage our mitochondria:

  • Free radicals left to roam freely steal electrons off the next closest stable molecule in their vicinity, damaging its molecular structure. This may be a fat molecule making up double membrane of the mitochondria or part of the mitochondrial DNA.
  • Damage may be minimal at first, but because mitochondria can self-replicate, defective mitochondria end up making even more defective mitochondria.
  • Symptoms start to become more apparent, with the first usually being a loss of energy as ATP production is compromised.
  • Hundreds of other vital cellular processes are also disrupted; eventually cells die. Our bodies enter a state of oxidative stress and symptoms become more widespread as the disruption starts to impact on the functioning of our brain, liver, heart, kidney, and several other organs. Whole body systems, such as our immune system, are also affected.

This is why scientists are now targeting mitochondria as a promising new avenue for the support of a whole raft of conditions believed to be due to mitochondrial dysfunction, sadly, a situation that gets more dire as we age.

How Mitochondria Impacts Aging?

free radicals impair proper mitochondria function

Source: https://www.nia.nih.gov/research/labs/lmg/unit-oxidative-dna-damage-processing-and-mitochondrial-functions

A paper published in The Journal of Clinical Investigation entitled, The role of mitochondria in aging, describes the MFRTA theory to be based on several observations:

  • Mitochondrial ROS (Reactive Oxygen Species, aka, free radicals) production increases with age because of a decline in mitochondrial function;
  • Activity of several ROS-scavenging enzymes declines with age;
  • Mutations of mitochondrial DNA accumulate during aging; and then...
  • A vicious cycle occurs whereby mitochondrial mutations impair the set of metabolic reactions and processes requiring oxygen that takes place in the mitochondria to convert the energy stored in macronutrients to ATP (mitochondrial respiration), resulting in a further increase in ROS production and accumulated oxidative damage to proteins, lipids, and DNA.

Thus, according to the MFRTA, mitochondria play a crucial role in mediating and amplifying the oxidative stress that drives the aging process.

Another eye-opening paper, The Mitochondrial Basis of Aging, examines how the degradation of healthy mitochondria function is associated not only with aging itself, but correlated with the development of a wide range of age-related diseases, such as cellular senescence, chronic inflammation and the age-dependent decline in stem cell activity.

The paper concludes:

"... mitochondria influence or regulate a number of key aspects of aging, and suggest that strategies directed at improving mitochondrial quality and function might have far-reaching beneficial effects."

At this point we know that our mitochondria:

  • Are essential "powerhouse" organelles in our cells that produce the energy we need to live;
  • Degrade over time as we age and are impacted by environmental factors or lifestyle choices, causing downstream havoc to our brain, liver, heart, kidney, several other organs, and immune system; but
  • Can maintain their robust function by eliminating or improving detrimental environmental vectors and poor lifestyle choices, along with supplementation with an improved form of CoQ10 called MitoQ®.

Now it's time to dig into why MitoQ® is so especially valuable for robust mitochondria function.

Which MitoQ Formula Is Right For You?

Which MitoQ is best for you?

In addition to the basic mitochondria-focused MitoQ®, ProHealth Longevity offers four other MitoQ formulations, each targeted to support a specific health concern. Take a look at how the orginal MitoQ® formula is blended with the certain compounds tailored to address your health issues. 

MitoQ® Heart

MitoQ Heart is scientifically formulated to support optimal Cardiovascular Health. In addition to a full daily recommended dose of our breakthrough MitoQ 5mg formula, it also includes effective levels of heart health ingredients Vitamin D3, Magnesium and L-Carnitine.

✓ Healthy heart function

✓ Optimal cardiovascular performance

✓ Supports flexible arteries

✓ Supports blood pressure in the normal range

MitoQ® Liver

MitoQ Liver is designed to support healthy liver performance and the repair of oxidative damage. In addition to a full daily recommended dose of our breakthrough MitoQ 5mg formula, Selenium, Choline and Siliphos® Milk Thistle round out this effective supplement.

Supports:

✓ Liver health

✓ Energy storage

✓ Fat metabolism

✓ Natural blood purification

MitoQ® Blood Sugar

With research-backed exceptional ingredients, MitoQ Blood Sugar directly supports natural sugar metabolism, healthy insulin levels and key organ health. In addition to a full daily recommended dose of our breakthrough MitoQ 5mg formula, we also include Zinc, Chromium and Cinnamon Extract.

Supports:

✓ Blood sugar and insulin levels within normal limits

✓ Organ health

MitoQ® Eye

MitoQ Eye is a revolutionary eye health formula that supports normal vision, eye health and retinal function in a way that has never been possible. In addition to a full daily recommended dose of our breakthrough MitoQ 5mg formula, is an extensive ingredient list including Vitamin E, Zinc, Mirtogenol® extract, Pycnogenol® French Maritime Pine extract, FloraGLO® Lutein and Optisharp® Zeaxanthin from Marigold extract.

Supports:

✓ Normal vision

✓ Eye health

✓ Tear function

Many supplements have little scientific support that attests to their efficacy. This is not so with the MitoQ® line of supplements. Since its founding MitoQ has spent more than $60 million supporting research into the impact of MitoQ® supplements in a wide range of health conditions with leading research institutions around the world. The work that's been done validates the link between mitochondrial dysfunction and health, and also the impact MitoQ® has on supporting the health of our cells, organs and our overall wellness.

Give MitoQ® a try.

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