The Many Ways Curcumin Benefits Your Long-term Health

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The Many Ways Curcumin Benefits Your Long-term Health

Everywhere you turn these days, there's some article extolling the many ways that curcumin benefits a broad range of health issues that we commonly struggle with, particularly as we age.

Can curcumin really be so beneficial to your health?

Yes, it appears so -- this most important active compound of turmeric is a potent supplement that's proven to help fight everything from chronic inflammation to cognitive function. After you read this piece and watch the video, it's likely that you'll agree that curcumin is worth including in your mix of supplements, as long as you ensure that the brand you choose has taken steps to improve it by making it absorbable.

None does this better than our Longvida® Curcumin, a breakthrough formula, which I'll tell you plenty about in a moment, but first I want to give you a glimpse of what I'm referencing when I extoll the many health benefits offered by curcumin. Consider these conclusions made by various scientific research studies:

Scientific studies show that curcumin benefits are numerous, as it can help improve blood pressure, arterial blood flow, digestion, blood sugar, eye health and more.

(Click image to enlarge.)
(Source)

Those headlines tout curcumin's capacity to improve your health in many ways. In this article, I want to tell you about three ProHealth Longevity curcumin supplements optimized to address four specific health conditions that typically worsen as we get older:

  1. Chronic inflammation that is behind many health issues, such as arthritis;
  2. Brain function (mood and cognition);
  3. Cardiovascular health (including cholesterol); and
  4. Chronic inflammation and cellular oxidation (free radicals).

While we remain proud of our basic Optimized Curcumin Longvida® product, ProHealth has four additional curcumin-based formulas, each designed to help improve a specific health concern, in part by making the curcumin more absorbable, but also by combining it with specific compounds to address specific needs.

In all cases, we use Longvida®, which is the patented curcumin extract that makes our curcumin more absorbable and bioavailable. Then we add natural, polyphenols-rich compounds known to be beneficial to each respective health issue.

Since all of its curcumin supplements are enhanced with Longvida®, I want you to understand the potential benefits derived by it, and then delve into the additional enhancements that Prohealth makes to each curcumin product in order to optimize it for the specific health benefit it's designed to address.

✔ To combat inflammation and arthritis, we combined Longvida® with a special boswellia serrata extract called "WokVel®" The result is Optimized Curcumin Body and Joint, a supplement that amplifies curcumin and boswellia's bioavailability in order to help reduce inflammation and joint discomfort.

✔ To help improve mood and cognition, we combined Longvida® with a unique extract of Bacopa monnieri called "Bacognize® Extract" to enhance curcumin and bacopa's bioavailability. We call this product Optimized Curcumin Brain and Focus®.

✔ To tweak our curcumin to optimize its ability to help improve cardiovascular health, including inhibiting LDL oxidation, we created Optimized Curcumin with Pomegranate Extract, a combination of a potent pomegranate extract called Pomella® that, together with Longvida®, ensures that these medicinal compounds get absorbed in order work to improve your heart health.

✔ The newest entry to our line of curcumin products is our longevity formula called Longvida® Optimized Curcumin. In this case, to our absorbable Longvida® we added Neurophenol™, a proprietary blend of extracts from two polyphenols, blueberries and grapes. Polyphenols have been successfully tested in various animal models of cognitive function.

I keep mentioning the virtues of Longvida®, so let's take a closer look at why it's so valuable.

Longvida®, The Prohealth Curcumin Powerhouse

 Longvida's SLCP technology boosts curcumin's benefits to your health

(Source)

Curcumin contains the most medicinal properties among the curcuminoid compounds found in turmeric. Curcumin presents powerful anti-inflammatory effects and is a very strong antioxidant, which may be the two primary reasons for its widely cited effectiveness to help heal such a wide range of maladies.

Longvida® is a breakthrough formula of the natural antioxidant curcumin, and amps up curcumin's natural health benefits by dramatically improving its absorption and bioavailability.

Longvida® Optimized Curcumin was developed in collaboration with neuroscientists at UCLA and is optimized to deliver free curcumin into target tissues through the critical bioavailability requirements of permeability, solubility, and stability. [1]

So What Makes Longvida® Unique?

  • Longvida® is 65 times more bioavailable than regular curcumin.
  • Longvida® offers therapeutic levels of free (not deactivated/metabolized) curcumin.
  • Curcumin from Longvida® passes the blood-brain barrier.
  • Longvida® contains no metabolic inhibitors, volatile oils, or crude, unpurified ingredients.

Longvida® has been clinically tested. In one randomized, double-blind, placebo-controlled clinical trial, researchers administered 400 mg Longvida® or placebo to 60 adults between the ages of 60 and 85, and then tested their short-term and long-term cognitive performance. [2]

Researchers found that after just one hour of administration, Longvida® brought significant improvements in sustained attention and working memory when compared with placebo. After four weeks, researchers noted Longvida® to be associated with significant improvements to memory and mood. [2]

Given how dramatically Longvida® improves curcumin, Prohealth selected it to be the mainstay ingredient for all three of their curcumin supplements. In the five minute video below, Dr. Robert DiSilvestro touches on several reasons that you want to ensure that the curcumin you take is powered by Longvida®:


To review, these are some of the most significant points Dr. DiSilvestro makes in the video:

  • Curcumin is one of the only supplement ingredients known to impact most of the main targets responsible for cognitive function during normal aging.
  • With Longvida® curcumin, improvements were seen in markers for antioxidant functions that can protect the brain from oxidant damage, to which it's susceptible,
  • Longvida® curcumin also decreased the expression of a protein that could lead to problems in the brain, like premature senility, and a decrease in beta amyloid levels which is a marker for Alzheimer's.

Now that you have an appreciation for how Longvida® magnifies the health benefits of curcumin, let's examine how each of ProHealth's curcumin products addresses a specific health condition.

Prohealth Optimized Curcumin Body and Joint

I already covered why using Longvida® Curcumin distinguishes Prohealth's curcumin supplements from others, but when it comes to formulating our Optimized Curcumin Body and Joint to help alleviate joint pain, we added the most bioavailable form of boswellia serrata to enhance curcumin's natural capacity to support a healthy inflammatory response and enhance joint health.

Boswellia serrata
comes from the sap of the Boswellia tree and has been used for centuries in traditional Ayurveda medicine. The supplement research site, Examine.com, compiled the research on boswellia and reports that its anti-inflammatory effects can significantly suppress pain and immobility associated with arthritis, such as osteoarthritis, taking as little as a week to occur. They said:

"The reduction observed with Boswellia serrata for pain and other
symptoms of osteoarthritis are more profound than other
supplements including that of glucosamine." [3]

Boswellia might also be a healthier, effective substitute for Non-steroidal anti-inflammatories (NSAIDs) that many aging athletes use, as well as those suffering from Fibromyalgia and Chronic Fatigue Syndrome (ME/CFS), to relieve their chronic joint and muscle aches. [4]

Thus, it makes perfect sense to combine curcumin and boswellia, but Prohealth takes it one step further by matching its enhanced Longvida® Curcumin with an enhanced bioavailable form of boswellia called WokVel® Extract.

WokVel® Extract is a proprietary formula derived from Boswellia serrata. Here's what you need to know about it:

  • Wokvel® Extract is a clinically researched botanical ingredient that supports joint health and flexibility.*
  • Derived from Boswellia serrata, Wokvel® Extract is an all-natural, science-backed ingredient used for premium dietary supplements that promote joint health.
  • WokVel® processes Boswellia to make it bioavailable without altering the resin's nutrient profile.
  • Standardized to the natural-spectrum fingerprint of boswellic acids, Wokvel® is one of the only joint health ingredients shown to be bioavailable in human trials. [5]

The combination of Longvida® Curcumin and Wokvel® Extract:

  • Promotes a healthy inflammation response*
  • Promotes joint health and flexibility*
  • Passes the blood-brain barrier*
[*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.]

In summary, curcumin and boswellia serrata appear to have biochemical synergies that enhance healthy inflammation response and joint flexibility. Optimized Curcumin Body and Joint has been formulated with these two herbs into a single supplement using premium, potent, highly bioavailable extracts: Longvida® 400 mg and Bacognize® 666 mg.

If you consistently experience joint pain and/or chronic inflammation, think about supplementing with Prohealth's Optimized Body and Joint. I take one capsule in the evening, thinking that perhaps after a day of running amok my joints might need to calm down.

Prohealth Optimized Curcumin Brain and Focus

Optimized Curcumin Brain and Focus® by ProHealth is a powerful blend of two clinically tested nutrients that supports brain health and improved cognitive function:

  • Longvida® Curcumin,
  • and Bacognize® Extract.

    I'll describe Bacognize® Extract's effect on cognitive function in a moment. Although you already have an appreciation for Longvida® Curcumin, know that it also can help mitigate brain inflammation, which is thought to be a major cause of cognitive conditions like Alzheimer's disease.

    Curcumin supports the brain by improving oxygen flow and removing plaque build-up, including preventing the accumulation of the protein beta-amyloid, the main component of the amyloid plaques found in the brains of Alzheimer patients. This process may slow or prevent the progression of Alzheimer's disease. [6]

    UCLA researchers have isolated bisdemethoxycurcumin, the active ingredient of curcuminoids like curcumin, and found that it boosted immune cells called macrophages, which are necessary to clear the plaque in the blood samples from Alzheimer's patients. [7]

    Bacognize® Standardized Bacopa for Brain Health

    Although it's true that using Longvida® Curcumin by itself would provide excellent support to brain health, we decided to amplify its power by adding Bacognize® Extract to our Optimized Curcumin Brain and Focus® formulation.

    Bacognize® Extract is a standardized extract of bacopa monnieri that supplies a minimum 45% of the bacoside compounds most associated with its brain health benefits. Bacopa monnieri has been used in Ayurvedic medicine for hundreds of years and is renowned for its ability to support mental focus and improve memory. Also called "water hyssop" or "Brahmi", this herb may have multiple cognitive benefits; some researchers have referred to it as a "memory vitalizer." [8]

    The "bacosides"in Bacognize® Extract are natural phytonutrients that help boost neurotransmitters activity and thereby improve brain function. In addition to supplying antioxidant activity that may help protect brain cells, bacosides are believed to enhance acetylcholine, serotonin and GABA - brain neurotransmitters associated with sharp memory, mental clarity and bright mood.

    Bacosides have also been found in some animal research to boost cerebral blood flow, which may offer special benefits to ME/CFS sufferers whose foggy thinking has been partly attributed to poor blood flow to the brain.

    The Bacognize® Extract in Prohealth's Optimized Curcumin Brain and Focus is designed to mirror the spectrum of bacosides naturally found in Bacopa, staying true to the nutritional "fingerprint" that has made this herb an Ayurvedic brain health legend. [9]

    Bacognize® Extract has been shown in randomized, placebo-controlled clinical trials to support memory, focus, and mood:*

    • It supports healthy memory function and concentration*
    • It promotes a healthy inflammation response and joint health*
    • It passes the blood-brain barrier* [10]
    [*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.]

    Turning again to the supplement research site, Examine.com, we find that supplementing with bacopa monnieri may improve cognition by reducing anxiety, and is also reliable for improving memory formation. Bacopa interacts with the dopamine and serotonergic systems, but its main mechanism concerns promoting neuron communication. It does this by enhancing the rate at which the nervous system can communicate by increasing the growth of nerve endings, also called dendrites. [11]

    Here's Examine.com's summary of the research about bacopa monnieri affect on certain aspects of cognitive capacity:

    • Memory - Consensus of eight studies indicate that it "appears to reliably and effectively improve memory in both healthy persons and during cognitive decline."
    • Attention - One study noted improvements in attention in persons with attention deficit (ADD).
    • Anxiety - Two studies indicate that bacopa monnieri can prevent rises in anxiety, although not necessarily reduce it.
    • Forgetting - A small reduction of acute forgetting has been noted, which may contribute better to long term memory (ie. grasping concepts better). [12]

    Bacosides have also been found in some animal research to boost cerebral blood flow, which may offer special benefits to ME/CFSsufferers whose foggy thinking has been partly attributed to poor blood flow to the brain. Some early human research showed positive results, as well.

    In one randomized, double-blind, placebo-controlled study, subjects were given either 300 mg bacopa monniera or placebo daily for a span of 12 weeks. Subjects were tested for their cognitive performance before supplementation, at the five-week mark, and at the study's conclusion at week twelve. Researchers reported the Bacopa group seemed to have significant improvements in speed of information processing, learning rate, memory and mood (calmness). [13]

    In summary, with familiar roots in Ayurvedic traditions - and like with curcumin and boswellia serrata - curcumin and bacopa monnieri may have complementary biochemistry that work together to enhance cognitive function. ProHealth's Optimized Curcumin Brain & Focus has formulated these two herbs into a single supplement using premium, potent, highly bioavailable extracts: Longvida® 400 mg and Bacognize® 600 mg.

    Anyone who is concerned about their memory, mood and/or mental sharpness should consider supplementing with these enhanced, legendary brain health botanical extracts paired together in Optimized Curcumin Brain & Focus. I take one capsule in the morning when I need all the added brainpower I can muster.

    Prohealth Optimized Curcumin with Pomegranate

    Optimized Curcumin with Pomegranate Extract by ProHealth is a superior blend of Longvida® Curcumin and a pomegranate extract called Pomella®.

    Pomegranates are polyphenols-rich, red-skinned fruits that contain a large amount of small, edible seed-like casings called "arils", an excellent source of Punicalagins and Punicic acid.

    Scientists at Verdure Sciences® created the Pomella® extract such that it captures the same nutrient profile as exists in the pomegranate fruit and juice, a key discovery since these antioxidants depend on an intrinsic ratio of nutrients to survive digestion and maximize absorption to deliver the powerful antioxidant effects observed by researchers.

    The best pomegranate extract will contain a ratio of punicalagins, or "polyphenol bombs" (so called due to their antioxidant density), and other naturally-occurring nutrients. Currently, Pomella® extract is the only pomegranate extract that contains the exact nutrient profile needed to deliver the health benefits linked to pomegranates.

    Let's examine Pomella® bioavailability, antioxidant potency, its effect on LDL (the "bad" cholesterol), cardiovascular health and diabetes.

    The nutrient profile combined with its bioavailability is what makes Pomella® unique.

    Although punicalagins are rich in potent antioxidants, containing about three times more than red wine and green tea, only about 6% enter the bloodstream after oral ingestion. This poor absorption presented an opportunity to Verdure Sciences®, the company that has patented Pomella® through an extraction method that captures the full antioxidant profile naturally found in pomegranates. [14] [15]

    By now, this bioavailable-enhancing quality of Prohealth's curcumin supplements is familiar. It's the poor bioavailablity of curcumin that lead Prohealth to use Longvida® Curcumin in all its curcumin products, and why the company chose Pomella® for their Optimized Curcumin with Pomegranate Extract.

    Pomella® was evaluated in a pharmacokinetic study - The Pomella® Absorption Study - that proved the extract enhanced the capacity for these polynutrients to reach the bloodstream where it can still be detected in the body 48 hours after consumption and reach targeted tissues. Additionally, metabolites of punicalagins have been found to accumulate in the body's organs, where they act to provide tangible health benefits. [16] [17]

    Pomella® Is More Rich in Antioxidants than Grape Seeds and Green Tea

    Pomella® Extract antioxidants in the body (as measured in the blood) exceed grape seed and green tea extracts, as shown in the graph below:

    Pomella extract added to curcumin amplifies curcumin benefits as concerns cardiovascular health(Source)

    Pomella® Extract has undergone extensive antioxidant testing at multiple independent labs. In a study published in 2006, it significantly increased human plasma Oxygen Radical Absorption Capacity (ORAC) by an average of 32% after consumption. This means that Pomella® Extract is a powerful antioxidant BOTH in the test tube and in the body, where it matters. [18]

    Pomella® May Improve Cardiovascular Health, Including Inhibiting LDL Oxidation

    The antioxidant profile of pomegranate polyphenols may offer unusual cardiovascular benefits. As a scavenger of free radicals in the bloodstream, punicalagins and natural spectrum pomegranate polyphenols help regulate the degree of oxidation of proteins, macrophages, lipoproteins, and vascular endothelial cells. Punicalagins and pomegranate polyphenols also assist in the regulation of several enzymes that control vessel dilation (via nitric oxide) and promote overall endothelial health. (Endothelial cells form the linings of the blood vessels.) The end result maximizes healthy blood flow and circulation, crucial keys in maintaining optimal cardiovascular health. [19]

    A research team from India in 2016 looked at how Pomella® Extract might help those suffering from heart disease. They divided 100 heart attack patients into two groups. Fifty took 300 mg of the extract twice daily for a month, while the remaining patients took an equal placebo. At the end of the month, those who took the extract had lower levels of heart disease indicators homocysteine, Hs-CRP, and OX-LDL, while simultaneously increasing HDL (good) cholesterol substantially. [20]

    The same Indian team also observed 40 of the patients with diabetes in conjunction to heart health ailments. Blood glucose levels and HbA1c levels for the patients who took the Pomella® Extract fell significantly over the course of the study.

    Pomella® Extract has been shown to inhibit LDL oxidation (see bar chart below). When LDL cholesterol particles in your body react with free radicals, the oxidized LDL itself then becomes more reactive with the surrounding tissues, which can produce tissue damage.


    Curcumin benefits are magnified by adding Pomella to inhibit LDL oxidation.

    (Source)

    People with high levels of LDL oxidation are three to five times more likely to develop metabolic syndrome over the next five years and face a fourfold risk of developing coronary heart disease. [21]

    Researchers from the Srikot Research Institute tested Pomella® and found a significant improvement in mean levels of total cholesterol, triglycerides, HDL, LDL, non-HDL cholesterol, serum homocysteine, hs-CRP and OX-LDL after add-on treatment with Pomella® compared to placebo. [22]

    In summary, Optimized Curcumin with Pomegranate Extract:

    • Captures the full antioxidant profile as found naturally in pomegranates*
    • Supports joint health, flexibility and a healthy inflammatory response*
    • Offers incredible potential to protect brain cells responsible for memory*
    [*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.]

    ProHealth's Optimized Curcumin with Pomegranate Extract contains Longvida® 200 mg and Pomella® 300 mg. Anyone concerned about cardiovascular health, high LDL or high blood sugar should consider supplementing with the only supplement on the market pairing Longvida® and Pomella® in one capsule. I take one capsule in the afternoon.

    Prohealth Optimized Curcumin

    Optimized Curcumin Longevity by ProHealth combines Longvida® curcumin with a proprietary extract of flavonoids from wild blueberries and grapes called Neurophenol™.

    Berries and grapes are high in antioxidants. Their flavonoids play a significant role in memory support and a healthy aging brain. [23]
    Flavonoids are phytonutrients (also known as phytochemicals) that are found in most fruits and vegetables - often concentrated in the skins - that are responsible for giving them their color hue, scent and flavor. The best known phytonutrients are the carotenoids, flavonoids, polyphenols, indoles, lignans and isoflavones.

    Polyphenols contained in berries and grapes may have multiple physiological effects that serve to support healthy brain function. Blueberry, strawberry, blackberry, grape, plum juice, and their extracts, have all been successfully tested in various animal models of cognitive function. Studies in which elderly subjects consumed grape or blueberry juice daily for 12 weeks noted a significant benefits in verbal learning memory. [24]

    Neurophenol™ provides flavonoids from standardized extracts of wild blueberry and grape such as anthocyanidins, monomers, dimmers and oligomers. Various studies indicate that plant-derived polyphenols, such as those offered by Optimized Curcumin Longevity, improve the oxidative and inflammatory stress that can lead to various chronic diseases. [25] [26]

    Optimized Curcumin Longevity by ProHealth is a unique formula containing Longvida® Optimized Curcumin and Neurophenol™. The combination of the super-absorbable Longvida® Optimized Curcumin with the proprietary blend of standardized blueberry and grape extracts in Neurophenol™, yields a curcumin-enhanced supplement that might help to:

    • Lower chronic inflammation
    • Fight free radicals, and
    • Improve cognitive capacity

    Optimized Curcumin Longevity contains 400 mg of Longvida® Optimized Curcumin Extract and 400 mg of proprietary Neurophenol™ blend in each serving.

    Your Takeaway

    Remember these three things:

    1. Curcumin can help improve your health in many ways, from reducing chronic inflammation and free radical damage to improving cognitive and cardiovascular health.

    2. Despite the wide range of curcumin benefits that can be had by its use, typically much of it does not get absorbed into your bloodstream, which is why the Longvida® technology was developed, as it dramatically improves bioavailablity.

    3. Curcumin can be made more potent for specific applications by pairing it with other compounds known to improve specific health conditions, such as arthritis and joint pain, brain health, cardiovascular health and the growing inflammation and free radical damage that occurs with aging.

      If you haven't already done so, sign up for our Newsletter, Longevity Today, and receive $25 off your purchase of the curcumin supplement you most need, or any other supplement offered by ProHealth Longevity. Just go to the home page and scroll down to the sign-up form.

      Show references


      1. http://www.longvida.com/
      2. http://www.prohealth.com/library/showarticle.cfm?libid=20651
      3. https://examine.com/supplements/boswellia-serrata/
      4. http://www.prohealth.com/fibromyalgia/library/showarticle.cfm?libid=20619
      5. http://www.wokvel.com/
      6. https://www.garmaonhealth.com/nine-reasons-curcumin-supplementation-can-improve-your-health/
      7. https://www.sciencedaily.com/releases/2007/07/070716190856.htm
      8. https://www.prohealth.com/library/can-botanicals-beat-brain-fog-enhance-cognitive-function-36058
      9. Ibid
      10. https://www.prohealthlongevity.com/products/prohealth-optimized-curcumin-brain-and-focus-60-capsules-ph409?_pos=6&_sid=88faf6486&_ss=r
      11. https://examine.com/supplements/bacopa-monnieri/
      12. Ibid
      13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153866/
      14. https://examine.com/supplements/punicalagins/
      15. https://web.archive.org/web/20171024225050/http://www.prohealth.com:80/library/showarticle.cfm?libid=30003
      16. https://www.ncbi.nlm.nih.gov/pubmed/16988113?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
      17. https://www.ncbi.nlm.nih.gov/pubmed/18598186
      18. https://www.ncbi.nlm.nih.gov/pubmed/17090147?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
      19. http://www.pomextract.com/
      20. https://web.archive.org/web/20171024225050/http://www.prohealth.com:80/library/showarticle.cfm?libid=30003
      21. http://www.clevelandheartlab.com/wp-content/uploads/2015/09/OxLDL-Practitioner-One-Pager-CHL-D007d.pdf
      22. https://www.naturalproductsinsider.com/news/2016/10/pomella-extract-helps-improving-cardio-metabolic.aspx
      23. https://www.ncbi.nlm.nih.gov/pubmed/28429081
      24. https://guardianlv.com/2013/08/blueberries-boost-memory-according-to-study/
      25. https://www.ncbi.nlm.nih.gov/pubmed/25616409
      26. https://www.tandfonline.com/doi/abs/10.1080/10408398.2013.767221?journalCode=bfsn20

       

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