Beneficial effects of resveratrol on vascular disease
Vascular problems are characterized by the accumulation of lipids and fibrous elements in the arteries, which can contribute to vascular diseases and health related sysmptoms. Resveratrol is a naturally occurring phytopolyphenol compound, and shows the ability to reduce the risk of build up in the arteries. In this review, beneficial effects of resveratrol on the initiation and progression of atherosclerosis - including:
- Regulation of vasodilator and vasoconstrictor production [blood pressure],
- Inhibition of oxidative stress/reactive oxygen species generation,
- Inhibition of modification of low-density lipoproteins ["bad" cholesterol],
- Anti-platelet aggregation [anti-clotting],
- And its abilities to impede progression and modulate complications of atherosclerosis - are discussed.
Source: Journal of Medicinal Food, Dec 2008;11(4):pp610-614. PMID: 19053850, by Fan E, Zhang L, Jiang S, Bai Y. College of Life Sciences, Nankai University, Tian Jin, People's Republic of China; Institute of Plant and Cell Physiology, Martin-Luther University, Halle/Saale, Germany; [E-mail: Enguo Fan, firstname.lastname@example.org]
Grape skin compound (resveratrol) fights the complications of high blood sugar Resveratrol could stop high blood sugar complications such as vascular problems, retinopathy and nephropathy, research finds.
Research carried out by scientists at the Peninsula Medical School in the South West of England has found that resveratrol, a compound present naturally in grape skin- and found in concentrated amounts in resveratrol supplements, can protect against the cellular damage to blood vessels caused by high production of glucose. This is according to a paper published in the April 2008 issue of the journal Diabetes, Obesity and Metabolism.
Elevated Glucose Damages Cellular Power Generators
The elevated levels of glucose that circulate in the blood of patients with diabetes causes micro- and macrovascular complications by damaging mitochondria, the tiny power plants within cells responsible for generating energy. When they are damaged they can leak electrons and make highly damaging ‘free radicals’. Complications that can result when this happens include nephropathy (kidney disease), heart disease and retinopathy (which if left untreated can lead to blindness).
Resveratrol Helps Cells Protect Themselves
Resveratrol stops the damage by helping cells make protective enzymes to prevent the leakage of electrons and the production of toxic 'free radicals'. As well as being naturally present in grape skins, resveratrol is also present in seeds, peanuts and red wine. Dr. Matt Whiteman, Principal Investigator and Senior Lecturer at the Institute of Biomedical and Clinical Science, Peninsula Medical School, commented: "Resveratrol's antioxidant effects in the test tube are well documented but our research shows the link between high levels of glucose, its damaging effect on cell structure, and the ability of resveratrol of protect against and mend that damage." He added: "Resveratrol or related compounds could be used to block the damaging effect of glucose which in turn might fight the often life threatening complications that accompany diabetes. It could well be the basis of effective diet-based therapies for the prevention of vascular damage caused by hyperglycaemia in the future."
Source: Peninsula Medical School news release, April 8, 2008