I so wanted this to work along with NMN Pro 500 but the resveratrol has caused muscle pain for me, mainly in both shoulders to the point I could not life either arm with out pain. I took 1 cap (500 mg) for approximately 10 days before I realized it was causing the discomfort. Once I stopped my pain cleared up almost immediately. I continue to take 250 mg of NMN and have no problem with it. Perhaps I started with to big a dose but I’m afraid to try it again. My concern is that the NMN will not work as well on its own but I’m hopeful and will continue with that.