Ten Remarkable Health Benefits of Melatonin

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Ten Remarkable Health Benefits of Melatonin

You may think that the benefits of melatonin only have to do with helping you to sleep. Although it's true that melatonin can encourage sleep and improve its quality, realize that sleeping better has a cascade effect that can improve your overall health. Regular, restorative sleep is essential to reduce stress, improve our immune defenses, fight cardiovascular disease and much more.

Examine.com, the supplement research website, reports the many benefits of melatonin, including general neuroprotective effects from the powerful antioxidants contained in melatonin. It also has several anti-cancer properties, says Examine.com, and is currently being investigated for its role in fighting breast cancer. Moreover, though melatonin does not appear to have much of an effect on lean mass or body fat, it may stop your body from gaining more fat. Melatonin supplementation also benefits eye health, possibly reduces tinnitus, and improve mood. 

There are many melatonin brands you can pick from, and they come in various forms. You can get tablets or capsules that you swallow, sublingual tablets you let dissolve under your tongue, and a relatively new delivery method - a liposomal spray.

I want to delve more into the benefits of melatonin derived from liposomal spray delivery, but first let's get a deeper appreciation of this pluripotent hormonal supplement. It’s important to know that, although melatonin does rapidly decline with age, you can still get the remarkable health benefits of melatonin via supplementation, particularly through the liposomal form.

What is Melatonin?

Melatonin is a hormone that was discovered in 1958. You may have heard it referred to as the "sleep hormone" because melatonin is well known for helping some people get a better night's sleep. This is true - melatonin is involved in regulating our internal body clock, but that capability just touches the surface of its deep health-promoting benefits.

Based on extensive research, scientists have discovered that melatonin has beneficial effects on everything from heart disease and diabetes, to bone health and obesity. Better yet, emerging science now suggests that it may protect our genetic material and guard against age related disease and decline. [1]

Melatonin is synthesized mainly in the pineal gland, but some is also synthesized in the retina, bone marrow and lymphocytes. The pineal gland and the retina synthesize melatonin in the absence of light, typically at night or in darkness. [2]

Let's now look at how melatonin can help improve sleep, the aging process, immunity, and the rest, which I've referred to as "ten remarkable health benefits of melatonin". After that, we’ll examine the liposomal delivery method of melatonin made by Quicksilver Scientific.

10 Remarkable Health Benefits of Melatonin

It's obvious that most chronic diseases correlate with age; meaning, that it takes time for whatever poor lifestyle habits we may have to create sufficient accumulated damage to cause a disease. The older we are, the more time we've had for bad habits to make us susceptible to heart disease, obesity, metabolic syndrome, diabetes and cancer. (Of course, there are heart-rending exceptions that happen to children.)

No supplement can fully compensate for a lifetime of bad health habits, but melatonin can help.

#1 The Sleep Benefits of Melatonin

As mentioned, melatonin is best known as a sleep enhancer, so let’s address this first.

Daylight reduces melatonin production. Blood levels of melatonin are low during the day, and high at night.

If you go to sleep between 10:00 and 11:00 PM, your natural melatonin production peaks between 2:00 and 4:00 AM. These peaks becoming substantially lower with advancing age after early childhood. The many sleep disturbances often experienced by the elderly may be explained by declining  melatonin production.

The three graphs below show when melatonin is naturally produced by the pineal gland at night, and how precipitously it declines with age.

First, look how melatonin production ebbs and flows during a 24-hour period. Notice how it peaks in the middle of the night:

 melatonin peaks in the middle of the night


Next, let's see how melatonin production declines as we get older:

 melatonin secretion declines as we age


At this point, you've seen that melatonin production declines as we get older, and that - irrespective of age - whatever amount we do produce occurs in the middle of the night. The next graph shows just how much that night time peak declines over time:

by age 50, we have melatonin little more than half of the melatonin produced in childhood


As you can see from the above graph, by the time you're 50 years old, you have little more than half of the melatonin production you enjoyed as a child!

#2 Age Better with Melatonin

As you've just observed in the above graphs, our melatonin plasma (blood) levels decline considerably as we get older. Lifespan studies on mice and rats have shown a significant lifespan increase as a result of melatonin supplementation when given to older rodents. [3]

Dr. Walter Pierpaoli is world renowned for the discovery of the biological clock in the pineal gland, the study of the molecules that regulate it. His experimental findings from 35 years of research has demonstrated the existence of a programmed "Aging Clock" in the pineal gland complex of the brain. He and his team have investigated the possible mechanisms and also the molecules that interact with melatonin, which are normally lost or deranged in the course of aging.

Dr. Pierpaoli has observed that zinc can completely correct aging-dependent immuno-depression and several other hormonal and metabolic alterations typical of aging, and that the low zinc levels in aging animals can be restored to normal values with nocturnal administration of melatonin. [4]

The observation of the powerful anti-aging and immuno-enhancing activity of the combination of zinc and melatonin suggests that you should consider adding zinc to your melatonin supplementation.

#3 Melatonin Is A Potent Antioxidant

Melatonin has been found to possess 200% more antioxidant power than vitamin E, and reduces oxidative damage better than glutathione, vitamins C and E. Its free-radical scavenging capabilities make it a potent force against many chronic diseases, such as heart disease and cancer. [5, 6]

In post-menopausal women, melatonin can inhibit lipid peroxidation (damage to your fat cells caused by free radicals), thus leading to decreased levels of low-density lipoprotein cholesterol (LDL), a primary contributor to atherosclerosis. [7]

#4 Melatonin Is An Immune System Enhancer

Immune system cells are typically vulnerable to free radical damage, which is why antioxidants such as melatonin are generally effective in boosting the immune system.

Melatonin is useful for both cellular and humoral immunity. Melatonin stimulates the production of the cytokines InterLeukin−2 (IL−2), InterLeukin−6 (IL−6), and InterLeukin−12 (IL−12). This means that these proteins and signaling molecules – which are expressed by white blood cells (the InterLeukins) – are an important part of your immune system capacity that’s enhanced by melatonin. [8]

#5 Melatonin Helps Maintain Cardiovascular Health

Since cardiovascular disease is the leading cause of death in the United States, melatonin's ability to protect against heart damage is especially noteworthy as a cardioprotective nutrient.

Animal studies have provided ample evidence supporting melatonin’s antioxidant protection against heart muscle injury, reducing the damage done by a heart attack and improving the strength of the heart’s pumping action following a heart attack.

Other studies report that melatonin decreases total cholesterol and LDL levels (the "bad" cholesterol), and increases HDL (the "good") cholesterol levels. Scientists have discovered that individuals with metabolic syndrome have a lower melatonin production rate compared to those without it, and that individuals with metabolic disturbances in blood pressure, cholesterol, and blood sugar management - all the classic features of metabolic syndrome - have lower melatonin levels than those with normal metabolic function.

#6 Melatonin May Be A Cancer Therapy Helper

Emerging research suggests that melatonin has anticarcinogenic properties; meaning it has the ability to prevent cancer from occurring, or to induce cancer cell death if cancer does occur. [9]

Melatonin might be able to do this due to its antioxidant, anti-inflammatory, anti-proliferative, and hormone-modulating properties. It has been successfully used in individuals with advanced stage cancers undergoing conventional anticancer therapy, by either slowing disease progression and/or decreasing treatment side effects.

In a review of eight randomized, controlled clinical trials evaluating the benefits of melatonin as an additional therapy for cancer patients with solid tumors undergoing chemotherapy or radiation therapy, researchers found that concurrent use of 20 mg of melatonin once daily versus conventional treatment alone, improved the rate of complete or partial remission by nearly 50%, increased the one-year survival rate by 45%, and decreased the devastating side effects of conventional therapy such as low platelet count, neuropathy, and fatigue by 89%, 83%, and 65% respectively, with no adverse events reported. [10]

#7 Melatonin Supports Healthy Glucose Levels

You can think of diabetes as belonging to the family of "free radical diseases", along with cardiovascular disease and cancer. Research has found that people with type 2 diabetes and retinopathy experience alterations of their melatonin secretion. [11]

Given that melatonin is a major free-radical scavenger (aka, antioxidant), it's not surprising that preclinical research repeatedly and consistently documents its beneficial antioxidative effects in diabetics and others with high blood sugar. [12]

Melatonin has also been shown to protect pancreatic beta-cells and several diabetes-affected organs (including kidney, retina, brain, and vasculature) from free radical damage. In various studies, melatonin treatment has produced reductions in blood glucose, hemoglobin A1c, and cholesterol. [13]

#8 Melatonin Plays A Role In Sustaining Cognitive Function

Intensive research over the past decade has indicated melatonin's beneficial effects in experimental models of neurodegenerative disorders and many central nervous system diseases, specifically those linked to oxidative damage. [14]

Although not conclusive, some studies suggest that melatonin may delay the onset of cognitive issues, and help protect vital cellular structures, such as mitochondria, from oxidative damage and decay. Declines in mitochondrial function are a hallmark feature of many neurodegenerative diseases. [15]

Preclinical studies revealed that melatonin exerts pronounced neuroprotective effects against beta amyloid plaque, one of the specific underlying causes of Alzheimer’s disease. [16, 17]

#9 Whittle Away Obesity With Melatonin

Obesity is often associated with stress, emotional eating, sleep-deprivation and hormonal changes later in life. 

A 2009 study of women with night eating syndrome (an eating disorder characterized by late-night binge eating) found that women suffering from this disorder had significant circadian melatonin rhythm disturbances, which also affected levels of cortisol (a stress hormone that can be a factor in weight problems) and ghrelin (a hormone that stimulates hunger). It also affected a variety of other behavioral and physiological circadian markers involved in appetite and neuroendocrine regulation. [18]

In middle-aged rodents, daily melatonin administration was found to suppress abdominal fat, plasma leptin levels, and insulin levels in middle-aged rodents, while also reducing body weight and food intake. Laboratory investigations also discovered melatonin’s ability to activate brown adipose tissue, which encourages your body to burn fat instead of storing it. [19]

#10 Reduce Osteoporosis Severity With Melatonin

Data derived from animal research suggests that melatonin has beneficial effects on bone repair and remodeling, as well as bone mineral density, which suggests that it might play a useful role in helping to reduce the severity of osteoporosis, or as adjuvant after bone fractures. [20]

A small double blind, placebo-controlled pilot study investigated the effects of melatonin on bone health and quality of life in 18 perimenopausal women (ages 45-54) for 6 months. It found that melatonin improved physical symptom scores (e.g., feeling and sleeping better), increased osteocalcin (a marker for bone formation), and decreased levels of Type-I collagen cross-linked N-telopeptide (a marker for bone resorption), indicating that melatonin may restore imbalances in bone remodeling and prevent bone loss. [21]

Liposomal Melatonin by Quicksilver Scientific

At this point you know a lot about the substantial health benefits of melatonin. Now it’s time to consider what kind of melatonin to take. I encourage you to consider a liposomal form, particularly that made by Quicksilver Scientific.

Quicksilver Scientific was founded by Dr. Christopher Shade, PhD, an industry thought-leader who has been collaborating with and informing health practitioners for more than a decade. As a cGMP certified company, Quicksilver Scientific health supplements are made according to cGMP regulations and strict quality control guidelines.

The Quicksilver Delivery Systems® signature trademark on their liposomal products sets them apart from other companies and ensures a superior product. This distinction is made by virtue of their smaller, more stable, single-layer spheres, making their liposomal delivery systems superior to the basic, commonplace liposomal technology. The difference is evident in the clarity of Quicksilver's liposomal products, which are only achievable with liposomes that are small enough to pass between cells and enter the bloodstream directly, guaranteeing optimal bioavailability.

Because as little as 15% of a dose of melatonin is actually absorbed by the body when swallowed, Dr. Shade, developed Quicksilver's liposomal melatonin liquid for enhanced uptake and nearly instantaneous effect. Liposomal melatonin may optimize cellular uptake and effectiveness and can be easily adjusted to a lower or higher dose to meet each individual’s needs.

ProHealth Longevity offers a wide variety of Quicksilver’s liposomal supplements, among them Liposomal Melatonin. You administer the melatonin by taking one pump of the liposomal dispenser by mouth, and hold for 30 seconds before swallowing. You only need one milligram due to the high bioavailability of this product's liposomal delivery.

Check out Dr. Shade's quick explanation about how his Liposomal Melatonin works to improve your sleep and overall health:

Show references
  1. http://www.ncbi.nlm.nih.gov/pubmed/16817850
  2. http://www.benbest.com/nutrceut/melatonin.html#negative
  3. http://www.antiageingconference.com/index.html?pg=pierpaoli10
  4. https://drpierpaoli.ch/ENG/what-melatonin-is-6f519000
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993480/
  6. https://www.ncbi.nlm.nih.gov/pubmed/15666035
  7. https://www.ncbi.nlm.nih.gov/pubmed/10739299
  8. http://www.immunityageing.com/content/2/1/17
  9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587994/
  10. https://www.ncbi.nlm.nih.gov/pubmed/22271210
  11. https://www.ncbi.nlm.nih.gov/pubmed/21629571
  12. https://www.sciencedirect.com/science/article/pii/S0303720711006095
  13. https://www.ncbi.nlm.nih.gov/pubmed/17944324
  14. https://www.ncbi.nlm.nih.gov/pubmed/20417677
  15. https://www.ncbi.nlm.nih.gov/pubmed/22391273
  16. https://www.ncbi.nlm.nih.gov/pubmed/10551770
  17. https://www.ncbi.nlm.nih.gov/pubmed/9030627
  18. https://www.ncbi.nlm.nih.gov/pubmed/19150931
  19. https://www.ncbi.nlm.nih.gov/pubmed/10650927
  20. https://link.springer.com/article/10.1007/s00784-012-0684-6
  21. https://www.ncbi.nlm.nih.gov/pubmed/22220591
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