Aerobic exercise increases BDNF levels, a protein involved in neurogenesis that promotes the survival, growth, and development of neurons.

Research indicates that ergothioneine can extend lifespan by guarding against the rapid shortening of telomeres. Telomeres are the caps at the ends of chromosomes that protect them from deterioration. As you age, your telomeres naturally shorten, which is a strong predictor of both lifespan and healthspan. Ergothioneine helps in maintaining telomere length, thus potentially offering a longer, healthier life. 

By engaging in regular physical and mental exercises, we can significantly improve our cognitive health and maintain our mental sharpness into ever older age.

Here's an overview of the tactics employed by the renowned physician and longevity expert, Dr. Peter Attia, on how to train for a fulfilling life at 100.